Panax ginseng cannot be cultivated on the same land consecutively for an extended time period, and the underlying mechanism regarding microorganisms is still being explored.
Optimal fertilizer application for and effect of soil water on root rot disease and saponin contents
Blind and excessive application of fertilizer was found during the cultivation of Panax notoginseng in field, as well as the increase of root rot disease incidence.
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Immunological benefits by ginseng through reciprocal regulation of Th17 and Treg cells during cyclosporine-induced immunosuppression
It is not clear whether ginseng affects cyclosporine (CsA)-induced desirable immunosuppressive action. In this study, we evaluated the immunological influence of combined treatment of ginseng with CsA.
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Protective effect of wild ginseng cambial meristematic cells on D-galactosamine-induced hepatotoxicity in rats
Panax ginseng has a wide range of biological activities including anti-inflammatory, antioxidant, and immunomodulatory functions. Wild ginseng cambial meristematic cells (CMCs) were obtained from P. ginseng cambium. This study examined the protective mechanism of wild ginseng CMCs against D-galactosamine (GalN)-induced liver injury. GalN, a well-known hepatotoxicant, causes severe hepatocellular inflammatory damage and clinical features similar to those of human viral hepatitis in experimental animals.
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A UPLC/MS-based metabolomics investigation of the protective effect of ginsenosides Rg1 and Rg2 in mice with Alzheimer’s disease
Alzheimer’s disease (AD) is a progressive brain disease, for which there is no effective drug therapy at present. Ginsenoside Rg1 (G-Rg1) and Ginsenoside Rg2 (G-Rg2) have been reported to alleviate memory deterioration. However, the mechanism of their anti-AD effect hasn’t yet been clearly elucidated.
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Drying characteristics and quality of red ginseng using far-infrared rays
The typical drying methods for red ginseng are sun drying and hot-air drying now. The purpose of this study was to investigate drying characteristics of red ginseng by using far-infrared drying.
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Up-regulation of heme oxygenase-1 by ginsenoside Ro attenuates lipopolysaccharide-induced inflammation in macrophage cells
The beneficial effects of ginsenoside species have been well demonstrated in a number of studies. However, the function of ginsenoside Ro (GRo), an oleanane-type saponin, has not been sufficiently investigated. Thus, the aim of the present study was to investigate the anti-inflammatory effects of GRo in vitro using the Raw 264.7 mouse macrophage cell line treated with lipopolysaccharide (LPS), and to clarify the possible mechanism of GRo involving heme oxygenase-1 (HO-1), which itself plays a critical role in self-defense in the presence of inflammatory stress.
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Inhibitory effects of [Ca] mobilization by total saponin from Korean red ginseng phosphorylation of PKA catalytic subunit and in human platelets
Intracellular Ca2+ ([Ca2+]i) is platelet aggregation-inducing molecule. Therefore, understanding the inhibitory mechanism of [Ca2+]i mobilization is very important to evaluate the antiplatelet effect of a substance. This study was carried out to understand the Ca2+-antagonistic effect of total saponin from Korean red ginseng (KRG-TS).
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Photosynthesis rates, growth and ginsenoside contents of 2-year-old grown at different light transmission rates in a greenhouse
Ginseng is a semi-shade perennial plant cultivated at sloping, sun-shading area in Korea. Recently, due to air-environmental stress and various fungal diseases, greenhouse cultivation has been suggested as an alternative. However, the optimal light transmission rate (LTR) in the greenhouse has not been established.
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Accumulation characteristics and correlation analysis of five ginsenosides in Panax ginseng from different cultivation regions and ages
Ginseng (the roots of Panax ginseng C. A. Meyer) is a well-known traditional oriental medicine and now it is widely used as a health food. It contains several types of ginsenosides, which are considered as the major active medicinal components of ginseng. It has recently been reported that qualitative and quantitative properties of ginsenosides found in ginseng may differ, depending on cultivation regions, grown ages, species and so on. So it is necessary to study the variation respect to cultivation ages and regions of the main ginsenosides in ginseng.
