In colorectal cancer (CRC), 40–60% of patients develop metastasis. The epithelial-mesenchymal transition (EMT) is a pivotal and intricate process that increases the metastatic potential of CRC. The aim of this study was to investigate the effect of Korean red ginseng extract (RGE) on colorectal metastasis through inhibiting of EMT and the metastatic abilities of CRC cells.
Category Archives: General
General posts.
A formulated red ginseng extract inhibits autophagic flux and sensitizes to doxorubicin-induced cell death
Ginseng is believed to have antitumor activity. Autophagy is largely a pro-survival cellular process that is activated in response to cellular stressors, including cytotoxic chemotherapy; therefore, agents that inhibit autophagy can be used as chemosensitizers in cancer treatment. We examined the ability of Korean red ginseng extract (RGE) to prevent autophagic flux and to make hepatocellular carcinoma (HCC) cells become more sensitive to doxorubicin.
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Microemulsion-based hydrogels for enhancing epidermal/dermal deposition of topically administered 20(S)-protopanaxadiol: and evaluation studies
20(S)-protopanaxadiol (20S-PPD) is a fully deglycosylated ginsenoside metabolite and has potent dermal anti-aging activity. However, due to its low aqueous solubility and large molecular size, a suitable formulation strategy is required to improve its solubility and skin permeability, thereby enhancing its skin deposition. Thus, we optimized microemulsion (ME)-based hydrogel (MEH) formulations for the topical delivery of 20S-PPD.
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GS-KG9 ameliorates a diabetic neuropathic pain induced by streptozotocin in rats
Diabetic neuropathy is one of the most devastating ailments occurring on peripheral nervous system. Neuropathic pain has been known to develop in about 30% of diabetics. Here, suppressive effect of GS-KG9 on neuropathic pain induced by streptozotocin (STZ) was examined.
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Enhanced Rg3 negatively regulates Th1 cell responses
Korean Red ginseng (KRG; Panax ginseng Meyer) is a widely used medicinal herb that is known to exert various immune modulatory functions. KRG and one of its purified components, ginsenoside Rg3, are known to possess anti-inflammatory activities. How they impact helper T cell-mediated responses is not fully explored. In this study, we attempted to evaluate the effect of Korean Red ginseng extract (KRGE) and ginsenoside-Rg3 on Th1 cell responses.
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High frequency somatic embryogenesis and plant regeneration of interspecific ginseng hybrid between and
Interspecific ginseng hybrid, Pgq (Panax ginseng × P. quenquifolius) has vigorous growth and produces larger roots than its both parents. However, the F1 progenies are complete male sterile. Plant tissue culture technology can be used to circumvent the issue and propagate the hybrid.
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Multicomponent assessment and ginsenosides conversions of L. roots before and after steaming by HPLC-MS
The structural conversions in ginsenosides induced by steaming or heating or acidic condition could improve red ginseng bioactivities significantly. In this paper, the chemical transformations of red American ginseng from fresh Panax quinquefolium L. under steaming were investigated and the possible mechanisms were discussed.
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Discovery of a new primer set for detection and quantification of in soils for ginseng cultivation
Korean ginseng is an important cash crop in Asian countries. However, plant yield is reduced by pathogens. Among the Ilyonectria radicicola-species complex, I. mors-panacis is responsible for root-rot and replant failure of ginseng in Asia. The development of new methods to reveal the existence of the pathogen before cultivation is started is essential. Therefore, a qRT-PCR method was developed to detect and quantify the pathogen in ginseng soils.
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Influence of organic acids and heat treatment on ginsenoside conversion
Heat treatments are applied to ginseng products in order to improve physiological activities through the conversion of ginsenosides, which are key bio-active components. During heat treatment, organic acids can affect ginsenoside conversion. Therefore, the influence of organic acids during heat treatment should be considered.
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Ginsenoside Rk1 ameliorates acetaminophen-induced hepatotoxicity in mice through inhibition of inflammation, oxidative stress, nitrative stress and apoptosis
Frequent overdose of acetaminophen (APAP) has become the major cause of acute liver injury (ALI). The present study was designed to evaluate the potential protective effects of ginsenoside Rk1 on APAP-induced hepatotoxicity and investigate the underlying mechanisms for the first time.
