Chong Myung-Tang (CMT) extract is being widely used in Korea as a traditional herbal tonic for increasing memory capacity in high school students and also for numerous body ailments since centuries. The use of CMT as to improve the learning capacity has been attributed to various plant constituents majorly black ginseng present in it. Therefore, in this study, we have first investigated whether black ginseng enriched CMT extracts affected spatial learning using Morris water maze test. Their molecular mechanism of action underlying improvement of learning and memory was examined in vitro.