Effects of Korean ginseng berry on skin anti-pigmentation and anti-aging via FoxO3a activation

The ginseng berry has various bioactivities, including anti-diabetic, anti-cancer, anti-inflammatory, and anti-oxidative properties. Moreover, we have revealed that the active anti-aging component of the ginseng berry, syringaresinol, has the ability to stimulate longevity via gene activation. Despite the many known beneficial effects of ginseng, its effects on skin aging are poorly understood. In this study, we investigated the effects of ginseng and the ginseng berry on one of the skin aging processes, melanogenesis and age-related pigment lipofuscin accumulation, to elucidate the mechanism of action with respect to anti-aging.