Ginsenoside compound K inhibits NF-κB by targeting Annexin A2

Ginsenoside compound K(C-K), a major metabolite of ginsenoside exhibits anti-cancer activity in various cancer cells and animal models. A cell signaling study has shown that C-K inhibited NF-κB pathway in human astroglial cells and liver cancer cells. However, the molecular targets of C-K and the initiating events were not elucidated.