Recently, we identified a novel ginseng-derived lysophosphatidic acid (LPA) receptor ligand, called gintonin. We showed that gintonin induces [Ca2+]i transient-mediated morphological changes, proliferation, and migration in cells expressing LPA receptors and that oral administration of gintonin exhibits anti-Alzheimer’s disease effects in model mice. However, little is known about the intestinal absorption of gintonin. The aim of this study was to investigate gintonin absorption using two model systems.
All posts by Byung-Hwan Lee, Sun-Hye Choi, Hyeon-Joong Kim, Sang-Deuk Park, Hyewhon Rhim, Hyoung-Chun Kim, Sung-Hee Hwang, Seung-Yeol Nah
Global analysis of ginsenoside Rg1 protective effects in -amyloid-treated neuronal cells
A number of reports have described the protective effects of ginsenoside Rg1 (Rg1) in Alzheimer’s disease (AD). However, the protective mechanisms of Rg1 in AD remain elusive.
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Effect of hydrothermal processing on ginseng extract
Panax ginseng Meyer has been cultivated because of its medicinal effects on immune system, blood pressure, and cancer. Major ginsenosides in fresh ginseng are converted to minor ginsenosides by structural changes such as hydrolysis and dehydration. The transformed ginsenosides are generally more bioavailable and bioactive than the primary ginsenosides. In this study, therefore, hydrothermal processing was applied to ginseng preparation to increase the yields of the transformed ginsenosides, such as 20(S)-Rg3, Rk1, and Rg5, and enhance antioxidant activities in an effective way.
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Pectinase-treated protects against chronic intermittent heat stress-induced testicular damage by modulating hormonal and spermatogenesis-related molecular expression in rats
Elevated testicular temperature disrupts spermatogenesis and causes infertility. In the present study, the protective effect of enzymatically biotransformed Panax ginseng Meyer by pectinase (GINST) against chronic intermittent heat stress-induced testicular damage in rats was investigated.
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HPLC analysis of phytosterols in the roots of grown under different conditions
The plant of Panax ginseng has been used as an herbal medicine. Phytosterols of P. ginseng with inhibitory effects on inflammation-related factors in HepG2 cells have been reported.
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Using Reverse Docking to Identify Potential Targets for Ginsenosides
Ginsenosides are the main ingredients of ginseng, which, in traditional Eastern medicine, has been claimed to have therapeutic values for many diseases. In order to verify the effects of ginseng which have been empirically observed we utilized reverse docking method to screen for target proteins that are linked to specific diseases.
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Ginsenoside Rg12, a new dammarane-type triterpene saponin from root
Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects.
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Non-saponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome
Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of non-saponin components of RGE have not been well studied.
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Evaluation of ginsenoside bioconversion of lactic acid bacteria isolated from kimchi
Panax ginseng is a physiologically active plant widely used in traditional medicine that is characterized by the presence of ginsenosides. Rb1, a major ginsenoside, is used as the starting material for producing ginsenoside derivatives with enhanced pharmaceutical potentials through chemical, enzymatic, or microbial transformation.
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Chronic saponin treatment attenuates damage to the pancreas in chronic alcohol-treated diabetic rats
Chronic heavy alcohol consumption may raise the risk of developing type 2 diabetes mellitus. Saponins inhibit apoptosis of pancreatic islet cells and reducing of lipid parameters. The present study was designed to investigate the effect of saponin on chronic ethanol-treated diabetic rats.
