The aim of the present study was to evaluate the potential protective effects of six ginsenosides (Rb1, Rb2, Rc, Rd, Rg1, and Rg3) isolated from Panax ginseng against tacrolimus (FK506)-induced apoptosis in renal proximal tubular LLC-PK1 cells.
All posts by Dahae Lee, Dong-Soo Lee, Kiwon Jung, Gwi Seo Hwang, Hye Lim Lee, Noriko Yamabe, Hae-Jeong Lee, Dae-Woon Eom, Ki Hyun Kim, Ki Sung Kang
Effect of Korean Red Ginseng intake on the survival duration of HIV-1 patients
Long-term ginseng intake can increase longevity in healthy individuals. Here we examined if long-term treatment with Panax ginseng C.A. Meyer (Korean Red Ginseng, KRG) can also enhance survival duration (SD) in patients with HIV-1 infection.
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Comparison of the anti-cancer activities of Korean Red Ginseng-derived fractions
Korean Red Ginseng (KRG) is an ethnopharmacological plant that is traditionally used to improve the body’s immune functions and ameliorate the symptoms of various diseases. However, the anti-tumorigenic effects of KRG and its underlying molecular and cellular mechanisms are not fully understood in terms of its individual components. In this study, in vitro and in vivo anti-tumorigenic activities of KRG were explored in water extract (WE), saponin fraction (SF), and non-saponin fraction (NSF).
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Biotransformation of extract by rat intestinal microflora: Identification and quantification of metabolites using LC-MS/MS
In general, after Panax ginseng is administered orally, intestinal microbes play a crucial role in its degradation and metabolization process. Studies on the metabolism of Panax ginseng by microflora are important for obtaining a better understanding of their biological effects.
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Effect of Korean red ginseng in chronic liver disease
Chronic liver disease (CLD), one of the most common diseases, typically arises from non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma (HCC). Therefore, there is a pressing need for improved treatment strategies. Korean red ginseng (KRG) has been known to have positive effects on liver disease and liver function. In this paper, we summarize the current knowledge on the beneficial effects of KRG on CLD, a condition encompassing NAFLD, alcoholic liver disease, chronic viral hepatitis, and HCC, as supported by experimental evaluation and clinical investigation.
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Anticancer activity and potential mechanisms of 1C, a ginseng saponin derivative, on prostate cancer cells
AD-2 (20(R)-dammarane-3b, 12b, 20, 25-tetrol; 25-OH-PPD) is a ginsenoside and isolated from P. ginseng, showing anticancer activity against extensive human cancer cell lines. In this study, effects and mechanisms of 1C ((20R)-3b-O-(L-alanyl)-dammarane-12b, 20, 25-triol), a modified version of AD-2, were evaluated for its development as a novel anticancer drug.
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Regulatory effects of Saponins from on colonic epithelial tight junctions in aging rats
Saponins from Panax japonicus (SPJ) are the most abundant and main active components of Panax japonicus, which replaces Ginseng roots in treatment for many kinds of diseases in minority ethnic group in China. Our previous studies have demonstrated that SPJ has the effects of anti-inflammation through MAPK and NF-κB signaling pathway. The present study was designed to investigate whether SPJ can modulate intestine TJ barrier in aging rats and further to explore the potential mechanism.
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Ginsenoside Rg promotes inflammation resolution through M2 macrophage polarization
Ginsenosides have been reported with many health benefits, including anti-inflammatory effects and the resolution of inflammation is now considered to be an active process driven by M2 type macrophages. In order to determine whether ginsenosides modulate macrophage phenotypes to reduce inflammation, 11 ginsenosides were studied with respect to macrophage polarization and the resolution of inflammation.
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Rare ginsenoside Ia synthesized from F1 by cloning and overexpression of the UDP-glycosyltransferase gene from : synthesis, characterization, and melanogenesis inhibition activity in BL6B16 cells
Ginsenoside F1 has been described to possess skin whitening effects on human. We aimed to synthesize a new ginsenoside derivative from F1 and investigate its cytotoxicity and melanogenesis inhibitory activity in B16BL6 cells using recombinant glycosyltransferase enzyme. Glycosylation has the advantage of synthesizing rare chemical compounds from common compounds with great ease.
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Metabolite profiling of fermented ginseng extracts by GC-MS
Ginseng contains many small metabolites such as amino acids, fatty acids, and carbohydrates as well as ginsenosides. However, little is known about the relationships between microorganisms and metabolites during the entire ginseng fermentation process. We investigate metabolic changes during ginseng fermentation according to the inoculation of food-compatible microorganisms.
