Chronic liver disease (CLD), one of the most common diseases, typically arises from non-alcoholic fatty liver disease (NAFLD), alcoholic liver disease, chronic viral hepatitis, or hepatocellular carcinoma (HCC). Therefore, there is a pressing need for improved treatment strategies. Korean red ginseng (KRG) has been known to have positive effects on liver disease and liver function. In this paper, we summarize the current knowledge on the beneficial effects of KRG on CLD, a condition encompassing NAFLD, alcoholic liver disease, chronic viral hepatitis, and HCC, as supported by experimental evaluation and clinical investigation.