We evaluated the drug interaction profile of red ginseng (RG) with respect to the activities of major cytochrome P450 (CYP) enzymes and the drug transporter P-glycoprotein (P-gp) in healthy Korean volunteers.
All posts by Dal-Sik Kim, Yunjeong Kim, Ji-Young Jeon, Min-Gul Kim
VASP-phosphorylation by ginsenoside Ro inhibits fibrinogen binding to αIIb/β in thrombin-induced human platelets
Glycoprotein IIb/IIIa (αIIb/β3) is involved in platelet adhesion, and triggers a series of intracellular signaling cascade, leading to platelet shape change, granule secretion and clot retraction. In this study, we evaluated the effect of ginsenoside Ro (G-Ro) on the binding of fibrinogen to αIIb/β3.
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Identification of mountain cultivated ginseng and cultivated ginseng using UPLC–oa-TOF MSE with a Multivariate Statistical Sample Profiling Strategy
The mountain cultivated ginseng (MCG) and cultivated ginseng (CG) both belong to the Panax ginseng, which have similar ingredients. However, their pharmacological activities are obviously different due to the significant differences in growth environment.
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Ginsenoside Rb1 and compound K improve insulin signaling and inhibit ER stress-associated NLRP3 inflammasome activation in adipose tissue
This study was designed to investigate whether ginsenoside Rb1 (Rb1) and compound K (CK) ameliorated insulin resistance by suppressing endoplasmic reticulum stress (ER stress)-induced inflammation in adipose tissue.
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The Change of ginsenoside composition in the Red ginseng () by the ultrasonication process
The result of USRG-12 indicates that the ultrasonication processed Red ginseng extracts (at 100°C) treated for 12 hrs produced the highest amount of ginsenoside Rg3 (0.803%), Rg5 (0.167%) and Rk1 (0.175%).
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In vitro and in vivo evaluation of Tissue-cultured mountain ginseng on penile erection
Progressed tissue culture techniques have allowed to easily obtain mass product of Tissue-Cultured Mountain Ginseng over 100 years old (TCMG-100). We investigated the effects of TCMG-100 extract on erectile function by in vitro and in vivo studies.
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Effects of gintonin on the proliferation, migration, and tube formation of human umbilical vein endothelial cells: involvement of lysophosphatidic acid receptors and VEGF signaling
Ginseng extracts are known to have angiogenic effects. However, to date, only limited information is available on the molecular mechanism underlying the angiogenic effects and the main components of ginseng that exert these effects. Human umbilical vein endothelial cells (HUVECs) are used as an in vitro model for screening therapeutic agents that promote angiogenesis and wound healing. We recently isolated gintonin, a novel ginseng-derived lysophosphatidic acid (LPA) receptor ligand, from ginseng.
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Assessment of microclimate conditions under artificial shades in a ginseng field
Knowledge on microclimate conditions under artificial shades in a ginseng field would facilitate climate-aware management of ginseng production.
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Canola oil is an excellent vehicle for eliminating pesticide residues in aqueous ginseng extract
We previously reported that two-phase partition chromatography between ginseng water extract and soybean oil efficiently eliminated pesticide residues. However, an undesirable odor and an unpalatable taste unique to soybean oil were two major disadvantages of the method. This study was carried out to find an alternative vegetable oil that is cost effective, labor effective and efficient without leaving an undesirable taste and smell.
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Total ginsenosides suppress monocrotaline-induced pulmonary hypertension in rats: involvement of nitric oxide and mitogen-activated protein kinases pathways
Ginsenosides have been shown to exert beneficial pharmacological effects on the central nervous, cardiovascular, endocrine systems. We sought to determine whether total ginsenosides (TG) inhibit monocrotaline (MCT)-induced pulmonary hypertension and to elucidate the underlying mechanism.
