Excessive stress will cause varied physiological and psychological disorders including male reproductive problems. Here, we tend to investigate the protective effects of Korean red ginseng (Panax ginseng Meyer; KRG) against sub-acute immobilization stress-induced testicular damage in experimental rats.
Preparative separation of minor saponins from leaves using biotransformation, macroporous resins and preparative high-performance liquid chromatography
Ginsenosides with fewer sugar moieties may exhibit better adsorptive capacity and more pharmacological activities.
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Effect of Korean red ginseng extracts on drug-drug interactions
Ginseng has been the subject of many experimental and clinical studies to uncover the diverse biological activities of its constituent compounds. It is a traditional medicine that has been used for its immunostimulatory, antithrombotic, antioxidative, anti-inflammatory, and anticancer effects. Ginseng may interact with concomitant medications and alter metabolism and/or drug transport, which may alter the known efficacy and safety of a drug; thus, the role of ginseng may be controversial when taken with other medications.
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Black Ginseng Activates Akt signaling, whereby Enhancing Myoblast Differentiation and Myotube Growth
Black ginseng (BG) has greatly enhanced pharmacological activities relative to white or red ginseng. However, the effect and molecular mechanism of BG on muscle growth has not been examined. In this study, we investigated whether BG could regulate myoblast differentiation and myotube hypertrophy.
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The effect of on the physiological properties of and on rhizospheric microbial diversity
Glomus intraradices is a species of arbuscular mycorrhizal fungi (AMF) that, as an obligate endomycorrhiza, can form mutually beneficial associations with plants. Panax ginseng is a famous traditional Chinese medicine; however, problems associated with ginseng planting, such as pesticide residues, reduce ginseng quality.
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Effect of Korean Red Ginseng extract on colorectal lung metastasis through inhibiting the epithelial-mesenchymal transition via TGF-β1/Smads signaling-mediated Snail/E-cadherin expression
In colorectal cancer (CRC), 40–60% of patients develop metastasis. The epithelial-mesenchymal transition (EMT) is a pivotal and intricate process that increases the metastatic potential of CRC. The aim of this study was to investigate the effect of Korean red ginseng extract (RGE) on colorectal metastasis through inhibiting of EMT and the metastatic abilities of CRC cells.
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A formulated red ginseng extract inhibits autophagic flux and sensitizes to doxorubicin-induced cell death
Ginseng is believed to have antitumor activity. Autophagy is largely a pro-survival cellular process that is activated in response to cellular stressors, including cytotoxic chemotherapy; therefore, agents that inhibit autophagy can be used as chemosensitizers in cancer treatment. We examined the ability of Korean red ginseng extract (RGE) to prevent autophagic flux and to make hepatocellular carcinoma (HCC) cells become more sensitive to doxorubicin.
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Microemulsion-based hydrogels for enhancing epidermal/dermal deposition of topically administered 20(S)-protopanaxadiol: and evaluation studies
20(S)-protopanaxadiol (20S-PPD) is a fully deglycosylated ginsenoside metabolite and has potent dermal anti-aging activity. However, due to its low aqueous solubility and large molecular size, a suitable formulation strategy is required to improve its solubility and skin permeability, thereby enhancing its skin deposition. Thus, we optimized microemulsion (ME)-based hydrogel (MEH) formulations for the topical delivery of 20S-PPD.
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GS-KG9 ameliorates a diabetic neuropathic pain induced by streptozotocin in rats
Diabetic neuropathy is one of the most devastating ailments occurring on peripheral nervous system. Neuropathic pain has been known to develop in about 30% of diabetics. Here, suppressive effect of GS-KG9 on neuropathic pain induced by streptozotocin (STZ) was examined.
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Enhanced Rg3 negatively regulates Th1 cell responses
Korean Red ginseng (KRG; Panax ginseng Meyer) is a widely used medicinal herb that is known to exert various immune modulatory functions. KRG and one of its purified components, ginsenoside Rg3, are known to possess anti-inflammatory activities. How they impact helper T cell-mediated responses is not fully explored. In this study, we attempted to evaluate the effect of Korean Red ginseng extract (KRGE) and ginsenoside-Rg3 on Th1 cell responses.
