Binding of adhesive proteins (i.e. fibrinogen, fibronectin, vitronectin) to platelet integrin glycoprotein IIb/IIIa (αIIb/β3) by various agonists (thrombin, collagen, ADP) involve in strength of thrombus. This study was carried out to evaluate antiplatelet effect of total saponin from Korean red ginseng (KRG-TS) by investigating whether KRG-TS inhibits thrombin-induced binding of fibrinogen and fibronectin to αIIb/β3.
Changes in the contents of prosapogenin in Red ginseng () depending on the extracting conditions
This study compared the contents of prosapogenin depending on the extracting conditions of Red ginseng to provide basic information for developing Red ginseng-based functional foods. The content of ginsenosides Rg3 reached their heights at 24 hrs of extraction, followed by 36 hrs and 72 hrs of extraction at 100°C.
Share this:
Alteration of saponin composition by overexpression and RNA interference of the protopanaxadiol 6-hydroxylase gene ()
The roots of Panax ginseng contain noble tetracyclic triterpenoid saponins derived from dammarenediol-II. Dammarene-type ginsenosides are classified into the protopanaxadiol (PPD) and protopanaxatriol (PPT) groups based on their triterpene aglycone structures. Two cytochrome P450 (CYP) genes (CYP716A47 and CYP716A53v2) are critical for the production of PPD and PPT aglycones, respectively. CYP716A53v2 is a protopanaxadiol 6-hydroxylase that catalyzes PPT production from PPD in P. ginseng.
Share this:
Increase in apoptotic effect of by microwave processing in human prostate cancer cells: and studies
Ginseng, which is widely used in functional foods and as an herbal medicine, has been reported to reduce the proliferation of prostate cancer cells by mechanisms that are not yet fully understood.
Share this:
Hippocampus-dependent cognitive enhancement induced by systemic gintonin administration
A number of neurological and neurodegenerative diseases shares impaired cognition as one of common symptoms. Therefore, the development of clinically applicable therapies to enhance cognition has yielded significant interest. Previously, we have shown that activation of lysophosphatidic acid receptors (LPARs) via gintonin application potentiates synaptic transmission by the blockade of K+ channels in the mature hippocampus. However, whether gintonin may exert any beneficial impact directly on cognition at the neural circuitry level and the behavioral level has not been investigated.
Share this:
Characterization of Korean Red Ginseng ( Meyer): history, preparation method, and chemical composition
It has been reported that Korean red ginseng has been manufactured since 1,123 years as described in the GoRyeoDoGyeong record. The Korean Red Ginseng manufactured by the traditional preparation method has its own chemical component characteristics. The ginsenoside contents of the red ginseng are shown as Rg1: 3.3 mg/g, Re: 2.0 mg/g, Rb1: 5.8 mg/g, Rc:1.7 mg/g, Rb2: 2.3 mg/g and Rd: 0.4 mg/g, respectively. It is known that Korean ginseng generally consists of the main root and the lateral or fine roots at a ratio of about 75: 25.
Share this:
Effects of cultivation ages and modes on microbial diversity in the rhizosphere soil of
Panax ginseng cannot be cultivated on the same land consecutively for an extended time period, and the underlying mechanism regarding microorganisms is still being explored.
Share this:
Optimal fertilizer application for and effect of soil water on root rot disease and saponin contents
Blind and excessive application of fertilizer was found during the cultivation of Panax notoginseng in field, as well as the increase of root rot disease incidence.
Share this:
Immunological benefits by ginseng through reciprocal regulation of Th17 and Treg cells during cyclosporine-induced immunosuppression
It is not clear whether ginseng affects cyclosporine (CsA)-induced desirable immunosuppressive action. In this study, we evaluated the immunological influence of combined treatment of ginseng with CsA.
Share this:
Protective effect of wild ginseng cambial meristematic cells on D-galactosamine-induced hepatotoxicity in rats
Panax ginseng has a wide range of biological activities including anti-inflammatory, antioxidant, and immunomodulatory functions. Wild ginseng cambial meristematic cells (CMCs) were obtained from P. ginseng cambium. This study examined the protective mechanism of wild ginseng CMCs against D-galactosamine (GalN)-induced liver injury. GalN, a well-known hepatotoxicant, causes severe hepatocellular inflammatory damage and clinical features similar to those of human viral hepatitis in experimental animals.
