Endophytic fungi play a very important role in balancing the ecosystem and boosting the growth of host. In the present study, we investigated the endophytic fungal diversity of healthy Panax notoginseng and evaluated their potential antimicrobial activity against five major phytopathogens causing root-rot of P. notoginseng.
Induction of Nrf2/ARE-mediated cytoprotective genes by red ginseng oil through ASK1-MKK4/7-JNK and p38 MAPK signaling pathways in HepG2 cells
The induction of cellular defensive genes such as phase II detoxifying and antioxidant enzymes is highly effective strategy for protection against carcinogenesis as well as slowing cancer development. Transcription factor Nrf2 is responsible for the activation of phase II enzymes induced by natural chemopreventive compounds.
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Effects of Panax ginseng extracts prepared at different steaming times on thermogenesis in rats
Panax ginseng (PG) has a long history of use in Asian medicine because of its multiple pharmacological activities. It has been considered that PG in a type of white ginseng may induce undesirable thermogenic effects, but not in a type of red ginseng. However, there is a lack of evidence about correlation between ginsenoside and thermogenesis.
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Fermented ginseng, GBCK25, ameliorates hemodynamic function on experimentally induced myocardial injury
In the present study, we investigated whether treatment of GBCK25 facilitated the recovery of hemodynamic parameters, left ventricle systolic pressure, left ventricular developed pressure (±dp/dt max) and electrocardiographic changes. GBCK25 significantly prevented the decrease in hemodynamic parameters and ameliorated the electrocardiographic abnormality. These results indicate that GBCK25 has distinct cardioprotectective effects in rat heart.
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An optimized microwave-assisted extraction method for increasing the yields of rare ginsenosides from Panax quinquefolius L
Rare ginsenosides in Panax quinquefolius L. are proved to have stronger bioactivities. The fact that it is hard to obtain large amounts of rare ginsenosides seriously restricts further researches of rare ginsenosides. An easy, fast and efficient method to obtain amounts of different kinds of rare ginsenosides at one time and to quantify precisely of each one is in great need.
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Converting panax ginseng DNA and chemical fingerprint into two-dimensional barcode
In this paper, we investigate how to convert Panax ginseng DNA sequence code and chemical fingerprint into two-dimensional code. In order to improve the compression efficiency, GATC2Bytes and DMC algorithms are proposed.
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NF-κB- and AP-1-mediated immunostimulatory activity of Compound K in monocytes and macrophages
Compound K (CK) is a bioactive derivative from ginsenoside Rb1 in Panax ginseng (Korean ginseng). Although its biological and pharmacological activities have been studied in various disease conditions, its immunomodulatory role in innate immunity mediated by monocytes/macrophages has been poorly understood.
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Molecular differentiation of Russian wild ginseng using mitochondrial nad7 intron3 region
Cultivated ginseng is often introduced as substitute and adulterant of Russian wild ginseng due to its lower cost or misidentification caused by similarity in appearance with wild ginseng. The aim of this study is to develop a simple and reliable method to differentiate Russian wild ginseng from cultivated ginseng.
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The interaction of serum albumin with ginsenoside Rh2 (G-Rh2) resulted in the downregulation of G-Rh2 cytotoxicity
Ginsenoside Rh2 (G-Rh2) is a ginseng saponin that is widely investigated because of its remarkable antitumor activity. However, its molecular mechanism by which (20S)G-Rh2 triggers its functions and how target animals avoid its cytotoxic action remains largely unknown.
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Changes in element accumulation, phenolic metabolism and antioxidative enzyme activities in the red-skin roots of Panax ginseng
Red-skin root disease has seriously decreased the quality and production of Panax ginseng (ginseng).
