Gastric ulcer (GU) is a common gastrointestinal disease that can be induced by many factors. Finding an effective treatment method that contains fewer side effects is important. 20 (S)-ginsenoside Rg3 is a kind of protopanaxadiol and has shown superior antiinflammatory and antioxidant effects in many studies, especially cancer studies. In this study, we examined the treatment efficacy of 20 (S)-ginsenoside Rg3 on GU.
Ginsenoside compound K inhibits NF-κB by targeting Annexin A2
Ginsenoside compound K(C-K), a major metabolite of ginsenoside exhibits anti-cancer activity in various cancer cells and animal models. A cell signaling study has shown that C-K inhibited NF-κB pathway in human astroglial cells and liver cancer cells. However, the molecular targets of C-K and the initiating events were not elucidated.
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Ginsenoside compound K inhibits NF-κB by targeting Annexin A2
Ginsenoside compound K(C-K), a major metabolite of ginsenoside exhibits anti-cancer activity in various cancer cells and animal models. A cell signaling study has shown that C-K inhibited NF-κB pathway in human astroglial cells and liver cancer cells. However, the molecular targets of C-K and the initiating events were not elucidated.
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Evaluation of the gastroprotective effects of 20 (S)-ginsenoside Rg3 on gastric ulcer models in mice
Gastric ulcer (GU) is a common gastrointestinal disease that can be induced by many factors. Finding an effective treatment method that contains fewer side effects is important. 20 (S)-ginsenoside Rg3 is a kind of protopanaxadiol and has shown superior anti-inflammatory and antioxidant effects in many studies, especially cancer studies. In this study, we examined the treatment efficacy of 20 (S)-ginsenoside Rg3 on GU.
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Endophytic Trichoderma citrinoviride isolated from mountain-cultivated ginseng (Panax ginseng) has great potential as a biocontrol agent against ginseng pathogens
Ginseng (Panax ginseng Meyer) is an invaluable medicinal plant containing various bioactive metabolites (e.g. ginsenosides). Due to its long cultivation period, ginseng is vulnerable to various biotic constraints. Biological control using endophytes is an important alternative to chemical control.
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Identification of 20(S)-protopanaxadiol metabolites in human plasma and urine using UPLC-Q-TOF
20(S)-Protopanaxadiol (PPD), the aglycone part of 20(S)-protopanaxadiol ginsenosides, possesses antidepressant activity among many other pharmacological activities. It is currently undergoing clinical trial in China as an antidepressant.
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Non-saponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression
Ginsenosides of Korean Red Ginseng extracts (RGE) and its saponin components suppress secretion of inflammasome-mediating cytokines while the non-saponin fraction (NS) of RGE oppositely stimulates cytokine secretion. Although direct exposure of NS to macrophages and mice induces cytokine production, oral administration of NS has not been studied in inflammasome-related disease model animals.
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Ginsenoside Rg1 activates ligand-independent estrogenic effects via rapid estrogen receptor signaling pathway
Ginsenoside Rg1 was shown to exert ligand-independent activation of estrogen receptor (ER) via mitogen-activated protein kinase (MAPK)-mediated pathway. Our study aimed to delineate the mechanisms by which Rg1 activates the rapid ER signaling pathways.
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Effect of Korean red ginseng in individuals exposed to high stress levels: A 6-week, double-blind, randomized, placebo-controlled trial
To investigate the neurobiological evidence supporting the adaptogenic effects of Korean red ginseng in reducing the harmful consequences of stress using a double-blind, placebo-controlled trial.
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Ginsenoside Rg3 suppresses mast cell-mediated allergic inflammation via MAPK signaling pathway
Ginsenoside Rg3 (G-Rg3) is the major bioactive ingredient of Panax ginseng and has many pharmacological effects including anti-adipogenic, anti-viral, and anti-cancer effects. However, the effect of G-Rg3 on mast cell-mediated allergic inflammation has not been investigated.
