Minor ginsenosides, low content in ginseng, have higher pharmacological activities. To obtain minor ginsenosides, the biotransformation of American ginseng PPD-ginsenoside was studied using special ginsenosidase type-I from Aspegillus niger g.848. The methods of DEAE-cellulose and PAGE were used in enzyme purification, TLC and HPLC were used in enzyme hydrolysis and kinetics; crude enzyme was used in minor ginsenoside preparation from PPD-ginsenoside; the products were separated with silica-gel-column, and recognised by HPLC and NMR.
Tag Archives: ginseng
Induction of systemic resistance in against by native HK34
Korean ginseng (Panax ginseng Meyer) is a perennial herb prone to various root diseases with Phytophthora cactorum as one of the most dreaded disease causing foliar blight and root rot. Although chemical pesticides are available for disease control, attention has been shifted to viable, eco-friendly and cost-effective biological means like plant growth promoting rhizobacteria (PGPR) for control of diseases.
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Ginseng total saponins attenuates myocardial injury via anti-oxidative and anti-inflammatory properties
Ginseng total saponin (GTS) has been shown to possess various ginsenosides. These ginsenosides is widely used for treating cardiovascular diseases in Asian communities. The aim of this study was to study the effects of GTS on cardiac injury after the global ischemia and reperfusion (I/R) in isolated guinea pig hearts.
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Review on the cases of patient risk associated with ginseng abuse and misuse
Ginseng has long been used as a functional food or therapeutic supplement and it is empirically known to be safe and non-toxic. During the past decades or so, a number of in vitro and in vivo experiments, as well as human studies have been conducted to prove the safety of various types of ginseng samples and their components.
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Ginsenoside Rb1 ameliorates liver fat accumulation by up-regulating perilipin expression in adipose tissue of db/db obese mice
Ginsenoside Rb1 (G-Rb1), the major active constituent of ginseng, improves insulin sensitivity and exerts anti-diabetic effects. We tested whether the insulin-sensitizing and anti-diabetic effects of G-Rb1 results from a reduction in ectopic fat accumulation, mediated by inhibition of lipolysis in adipocytes.
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20(S)-Protopanaxatriol inhibits release of inflammatory mediators in IgE-mediated mast cell activation
Anti-allergic effect of 20(S)-protopanaxatriol (PPT), an intestinal metabolite of ginseng saponins was investigated in the guinea pig lung mast cells (GPMCs) and mouse bone marrow-derived mast cells (BMMCs) activated by specific antigen/antibody reaction. Methods: Increasing concentrations of PPT were pretreated 5 min before antigen stimulation, and various inflammatory mediator releases and their relevant cellular signaling events were measured in those cells.
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A prebiotic fiber increases the formation and subsequent absorption of compound K following oral administration of ginseng in rats
Gut microflora play a crucial role in the biotransformation of ginsenosides to compound K (CK), which may affect the pharmacological effects of ginseng. Prebiotics, such as NUTRIOSE® could enhance the formation and consequent absorption of CK through modulation of gut microbial metabolic activities. In this study, the effect of a prebiotic fiber (NUTRIOSE®) on the pharmacokinetics of ginsenoside CK, a bioactive metabolite of ginsenosides, and its mechanism of action were investigated.
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Quality and Antioxidant Activity of Ginseng Seed Processed by Fermentation Strains
Fermentation technology is widely used to alter the effective components of ginseng. This study was carried out to analyze the characteristics and antioxidant activity of ginseng seeds fermented by Bacillus, Lactobacillus, and Pediococcus strains.
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Inhibition of L-type Ca current by ginsenoside Rd in rat ventricular myocytes
Ginsenoside Rd (GSRd), one of the most abundant ingredients of Panax ginseng, protects the heart by multiple mechanisms including the inhibition of Ca2+ influx. We intended to explore the effects of GSRd on L-type Ca2+ current (ICa,L) and define the mechanism of the suppression of ICa,L by GSRd.
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Effect of ginseng and ginsenosides on melanogenesis and its mechanism of action
Abnormal changes in skin color induce significant cosmetic problems and affect quality of life. There are two groups of abnormal change in skin color; hyperpigmentation and hypopigmentation. Hyperpimentation, darkening skin color by excessive pigmentation, usually are major concerns Asian people with yellow brown skin. A variety of hypopigmenting agents have been used, but the treating hyperpigmented condition is still challenging and the results are often discouraging. Panax ginseng has been used traditionally in eastern Asia to treat various diseases, due to its immunomodulatory, neuroprotective, antioxidative, and anti-tumor activities.
