The beneficial effects of ginsenoside species have been well demonstrated in a number of studies. However, the function of ginsenoside Ro (GRo), an oleanane-type saponin, has not been sufficiently investigated. Thus, the aim of the present study was to investigate the anti-inflammatory effects of GRo in vitro using the Raw 264.7 mouse macrophage cell line treated with lipopolysaccharide (LPS), and to clarify the possible mechanism of GRo involving heme oxygenase-1 (HO-1), which itself plays a critical role in self-defense in the presence of inflammatory stress.
Tag Archives: science
Inhibitory effects of [Ca] mobilization by total saponin from Korean red ginseng phosphorylation of PKA catalytic subunit and in human platelets
Intracellular Ca2+ ([Ca2+]i) is platelet aggregation-inducing molecule. Therefore, understanding the inhibitory mechanism of [Ca2+]i mobilization is very important to evaluate the antiplatelet effect of a substance. This study was carried out to understand the Ca2+-antagonistic effect of total saponin from Korean red ginseng (KRG-TS).
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Photosynthesis rates, growth and ginsenoside contents of 2-year-old grown at different light transmission rates in a greenhouse
Ginseng is a semi-shade perennial plant cultivated at sloping, sun-shading area in Korea. Recently, due to air-environmental stress and various fungal diseases, greenhouse cultivation has been suggested as an alternative. However, the optimal light transmission rate (LTR) in the greenhouse has not been established.
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Anti-proliferative activity of decoction products in HeLa cells
This study aims to investigate the effect of decoction process on the change of ginsenosides and relation with anti-proliferative effect in HeLa cells.
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Inhibitory mechanism of Korean Red Ginseng on GM-CSF expression in UVB-irradiated keratinocytes
Ultraviolet (UV)-irradiated keratinocytes secrete various proinflammatory cytokines. UV-induced skin damage is mediated by growth factors and proinflammatory cytokines such as granulocyte macrophage colony stimulating factor (GM-CSF). In a previous study, we found that saponin of Korean red ginseng (SKRG) decreased the expression of GM-CSF in UVB-irradiated SP-1 keratinocytes. In this study, we tried to find the inhibitory mechanism of SKRG on UVB-induced GM-CSF expression in SP-1 keratinocytes.
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Effect of Korean Red Ginseng treatment on the gene expression profile of diabetic rat retina
Korean Red Ginseng (KRG) is an herbal medicine used in Asian countries and is very popular for its beneficial biological properties. Diabetes mellitus (DM) and its complications are rapidly becoming a global public health concern. The literature on transcriptional changes induced by KRG in rat models of diabetic retinopathy is limited. Considering these facts, we designed this study to determine whether retinopathy-associated genes are altered in DM rat retinas and whether the induced changes are reversed by KRG.
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Kinetic study for the optimization of ginsenoside Rg3 production by heat treatment of ginsenoside Rb1
Ginsenoside Rg3 is a promising anticancer agent. It is usually produced by heat treating ginseng, in which ginsenoside Rb1 is the major ginsenoside. A kinetic study was conducted to optimize ginsenoside Rg3 production by the heat treatment of ginsenoside Rb1.
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Ginsenoside Re inhibits pacemaker potentials via ATP sensitive K channels and a cGMP/nitric oxide-dependent pathway in cultured interstitial cells of Cajal from mouse small intestine
Ginseng belongs to the genus Panax and its main active ingredients are called ginsenosides. Interstitial cells of Cajal (ICCs) are the pacemaker cells of the gastrointestinal (GI) tract. To understand the effects of ginsenoside Re (GRe) on GI motility, the authors investigated its effects on the pacemaker activities of ICCs of the murine small intestine.
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The inhibitory mechanism of crude saponin fraction from Korean Red Ginseng in collagen-induced platelet aggregation
Korean Red Ginseng has been used as a traditional oriental medicine to treat illness and to promote health for several thousand years in Eastern Asia. It is widely accepted that ginseng saponins, ginsenosides, are major active ingredients for Red ginseng’s therapeutic activity against many kinds of illness. Although crude saponin fraction (CSF) displayed anti-platelet activity, the molecular mechanism of its action remains to be elucidated.
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Ginsenoside Rd and ischemic stroke; a short review of literatures
Panax ginseng is a well-known economic medical plant which is broadly used in Chinese traditional medicine. This species contains unique class of natural products, namely ginsenosides. Recent clinical and experimental studies lined a plethora of evidences up for the promising role of ginsenosides on different diseases including neurodegenerative, cardiovascular, certain types of cancer, etc. Nowadays, much attention has been paid to ginsenoside Rd as neuroprotective agent to attenuate ischemic stroke damages.
