In recent years, several therapeutical drugs have been rationally designed and synthesized based on the novel knowledge gained from investigating the actions of biologically active chemicals derived from foods, plants, and medicinal herbs. One of the major advantages of these naturalistic chemicals is their ability to interact with multiple targets in the body resulting in a combined beneficial effect. Ginseng is a perennial herb (Araliaceae family), a species within the genus Panax, and a highly valued and popular medicinal plant.
Tag Archives: science
Oxidative stability of extracts from red ginseng and puffed red ginseng in bulk oil or oil-in-water emulsion matrix
Explosive puffing can induce changes in the chemical, nutritional, and sensory quality of red ginseng. The antioxidant properties of ethanolic extracts of red ginseng and puffed red ginseng were determined in bulk oil and oil-in-water (O/W) emulsions.
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Effects of fermented ginseng root and ginseng berry on obesity and lipid metabolism in mice fed a high-fat diet
Previous studies have shown that both ginseng root and ginseng berry exhibited anti-obesity and anti-diabetic effects. However, a direct comparison of the efficacy and mechanisms between the root and the berry after oral administration remains to be illuminated.
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Overexpression of ginseng causes organ fusion in the axillary leaf branch of
Glycosylation of natural compounds increases the diversity of secondary metabolites. Glycosylation steps are implicated not only in plant growth and development, but also in plant defense responses. Although the activities of uridine-dependent glycosyltransferases (UGTs) have long been recognized, and genes encoding them in several higher plants have been identified, the specific functions of UGTs in planta remain largely unknown.
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Effect of high-dose ginsenoside complex (UG0712) supplementation on physical performance of healthy adults during a 12-week supervised exercise program: A randomized placebo-controlled clinical trial
Ginseng has been used as an ergogenic agent, although evidence for its effectiveness is weak. A randomized, double-blind, placebo-controlled clinical trial was conducted to evaluate the effect of a ginsenoside complex (UG0712) on changes in exercise performance.
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Ginsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation
Panax ginseng is one of the most commonly used medicinal herbs worldwide for a variety of therapeutic properties including neurocognitive effects. Ginsenoside Rg1 is one of the most abundant active chemical constituents of this herb with known neuroprotective, anxiolytic and cognition improving effects.
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The comparative study on chemical composition of the total saponins extraction from fermented and white ginseng under the effect of macrophages phagocytotic function
In this study, we adopt the white ginseng as raw material, which was processed as fermented ginseng products with Paecilomyces hepiali through solid culture. The characteristic chemical markers of them were investigated by RRLC–Q-TOF-MS (rapid resolution liquid chromatography coupled with quadrupole time -of-flight mass spectromtry) method combined with multivariate statistical analysis.And the implications of these components on biological activity were investigated for the improvement of the phagocytic function of macrophages in Zebrafish.According to the established RRLC–QTOF-MS chemical profiling, the contents in ginsenosides of high molecular weight especially malonylated protopanaxadiol ginsenosides were slightly decrease due to the fermentation process, which were hydrolyzed into rare and minor ginsenosides.
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Korean Red Ginseng extract reduces hypoxia-induced epithelial-mesenchymal transition by repressing NF-κB and ERK1/2 pathways in colon cancer
The incidence of colorectal cancer (CRC) is increasing, with metastasis of newly diagnosed CRC reported in a large proportion of patients. However, the effect of Korean Red Ginseng extracts (KRGE) on epithelial to mesenchymal transition (EMT) in CRC is unknown. Therefore, we examined the mechanisms by which KRGE regulates EMT of CRC in hypoxic conditions.
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The skin protective effects of compound K, a metabolite of ginsenoside Rb1 from
Compound K (CK) is a ginsenoside, which is a metabolite of Panax ginseng. There is interest both in increasing skin health and anti-aging using natural skin care products. In this study, we explored the possibility of using CK as a cosmetic ingredient.
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Study on the grading standard of seedlings
The quality differences in seedlings of medicinal herbs often affect the quality of medicinal parts. The establishment of the grading standard of Panax notoginseng (P. notoginseng) seedlings is significant to the stable quality of medicinal parts of P. notoginseng.
