Panax ginseng is a traditional herb used for medicinal purposes in eastern Asia. P. ginseng contains various ginsenosides with pharmacological effects. In this study, floralginsenoside A (FGA), ginsenoside Rd (GRD), and ginsensoside Re (GRE) were purified from P. ginseng.
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New metabolites from the biotransformation of ginsenoside Rb1 by sp.229 and activities in inducing osteogenic differentiation by Wnt/β-catenin signaling activation
Ginseng is a well-known traditional Chinese medicine that has been widely used in a range of therapeutic and health-care applications in East Asian countries. Microbial transformation is regarded as an effective and useful technology in modification of nature products for finding new chemical derivatives with potent bioactivities. In this study, three minor derivatives of ginsenoside compound K were isolated and the inducing effects in Wnt signaling pathway were also investigated.
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Quality and Characteristics of Fermented Ginseng Seed Oil based on Bacterial Strain and Extraction Method
In this study, the fermentation of ginseng seeds was hypothesized to produce useful physiologically-active substances, similar to that observed for fermented ginseng root. Ginseng seed was fermented using Bacillus, Pediococcus, and Lactobacillus strains to extract ginseng seed oil, and the extraction yield, color, and quantity of phenolic compounds, fatty acids, and phytosterol were then analyzed.
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Effect of azoxystrobin fungicide on the physiological and biochemical indices and ginsenoside contents of ginseng leaves
The impact of fungicide azoxystrobin applied as foliar spray on the physiological and biochemical indices and ginsenosides contents of ginseng was studied in ginseng (Panax ginseng Mey. cv. ‘Ermaya’) under natural environmental conditions. Different concentrations of 25% azoxystrobin SC (150g a.i. /ha and 225 g a.i. /ha) on ginseng plants were sprayed three times and the changes in physiological and biochemical indices and ginsenosides contents of ginseng leaves were tested.
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Antinociceptive and anti-inflammatory effects of ginsenoside Rf in a rat model of incisional pain
Ginseng saponin has long been used as a traditional Asian medicine and is known to be effective in treating various kinds of pain. Ginsenoside Rf is one of the biologically active saponins found in ginseng. We evaluated ginsenoside Rf’s antinociceptive and anti-inflammatory effects, and its mechanism of action on adrenergic and serotonergic receptors, in an incisional pain model.
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Ginsenoside Rg5 prevents apoptosis by modulating HO-1/Nrf2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells
Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These finding also provide a part of molecular rationale for the role of Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage.
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Remarkable impact of steam temperature on ginsenosides transformation from fresh ginseng to Red ginseng
The temperature is an essential condition in Red ginseng processing. Pharmacological activities of Red ginseng in different steam temperature are significantly different.
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total protein promotes proliferation and secretion of collagen in NIH/3T3 cells by activating ERK pathway
Recently, the protein from ginseng has been studied and used for the treatment of several kinds of diseases. However, the effect of ginseng total protein (GTP) on proliferation and wound-healing in fibroblast cells still remains unclear.
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Compound K induced apoptosis via endoplasmic reticulum Ca release through ryanodine receptor in human lung cancer cells
Extended endoplasmic reticulum (ER) stress may initiate apoptotic pathways in cancer cells, and ER stress has been reported to possibly increase tumor death in cancer therapy. We previously reported that caspase-8 played an important role in compound K-induced apoptosis via activation of caspase-3 directly or indirectly through Bid cleavage, cytochrome c release, and caspase-9 activation in HL-60 human leukemia cells. The mechanisms leading to apoptosis in A549 and SK-MES-1 human lung cancer cells and the role of endoplasmic reticulum (ER) stress have not yet been understood.
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Genetic variability, associations and path analysis of chemical and morphological traits in Indian ginseng { (L.) Dunal} for selection of higher yielding genotypes
The study was done to assess the genetic variability present in Ashwagandha and to examine the nature of associations of various traits to the root yield of the plant.
