AKT-targeted anti-inflammatory activity of calyx ethanolic extract

Korean ginseng (Panax ginseng) plays an anti-inflammatory role in variety of inflammatory diseases such as gastritis, hepatitis, and colitis. However, inflammation-regulatory activity of the calyx of the P. ginseng berry has not been thoroughly evaluated. To understand whether the calyx portion of the P. ginseng berry is able to ameliorate inflammatory processes, an ethanolic extract of P. ginseng berry calyx (Pg-C-EE) was prepared, and LPS-activated macrophages and HEK293 cells transfected with inflammation-regulatory proteins were employed to test the anti-inflammatory action of Pg-C-EE.