Korean ginseng has been widely evaluated to treat human diseases; however, most studies on Korean ginseng have focused on its root. In this study, polysaccharides [acidic-polysaccharide-linked glycopeptide (APGP) extracted with 90% ethanol and hot water] were prepared from Korean ginseng berries, and their effect on immunosenescence was explored.
Monthly Archives: May 2017
Korean Red Ginseng extract and ginsenoside Rg3 have anti-pruritic effects on chloroquine-induced itch by inhibition of -mediated pathway
It was previously found that Korean Red Ginseng water extract (KRGE) inhibits histamine-induced itch signaling pathway in peripheral sensory neurons. Thus, in the present study, it was investigated whether KRGE may inhibit another distinctive itch pathway induced by chloroquine (CQ), a representative histamine-independent pathway mediated by MrgrpA3 and TRPA1.
Ginsenoside Rh2 epigenetically regulates cell-mediated immune pathway to inhibit proliferation of MCF-7 breast cancer cells
Ginsenoside Rh2 has been known to enhance the activity of immune cells as well as to inhibit the growth of tumor cells. Although the repertoire of genes regulated by Rh2 is well-known in many cancer cells, the epigenetic regulation has yet to be determined, especially for comprehensive approaches to detect methylation changes.
Influence of phytochemical composition on antioxidant and reducing activities of Indian ginseng [ (L.) Dunal] root extracts
Roots of Withania somnifera (WS) are a celebrated medicinal ingredient in Ayurvedic and many other indigenous systems of medicine. The present study investigates the effect of the phytochemical composition of the extracts on their antioxidant and reducing activities.
GBCK25, fermented ginseng, attenuates cardiac dysfunction in high fat diet-induced obese mice
The fermentation of medicinal herbs facilitated by microbes is assumed to exert promising therapeutic efficacy on the absorption, bioavailability, and pharmacological effects by speed up the making or conversion of active constituents into their metabolites. We examined the cardioprotective potential of fermented ginseng, GBCK25, against high-fat diet (HFD)-induced metabolic and functional illnesses as following the essential analysis such as electrocardiographic parameters, alterations of body and organ weights, echocardiographic studies.
Korean Red Ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by down-regulating p38 MAPK and NF-κB signaling pathways
The potential therapeutic values of Korean Red Ginseng extract (KRGE) in autoimmune disorders of nervous system have not been fully investigated yet.