s: Acute hepatic failure (ALF) is life-threatening critical condition in which rapid deterioration of liver function and liver transplantation. Several studies have showed that Panax Ginseng Mayer has antidiabetic and hepatoprotective effect. However, the hepatoprotective effect of ginseng berry is still unveiled. In this study, we evaluated the hepatoprotective effects of ultrasonication processed ginseng berry extract (UGBE) on ALF model in rats.