Abstract: Background: Many glaucoma patients have difficulty in using anti-glaucoma eye drops due to dry eye symptom. In this prospective, randomized, double-blind, placebo-controlled study, we evaluated the effect of Korean red ginseng on dry eye syndrome in glaucoma patients treated with anti-glaucoma eye drops.Methods: Forty nine participants were allocated to the Korean red ginseng (3 g/day; n = 24) or placebo (n = 25) groups for 8 weeks. Tear film stability, fluorescein corneal staining, conjunctival hyperemia, tear production, the grade of meibomian gland dysfunction, and dry eye questionnaire (Ocular Surface Disease Index) were evaluated at baseline and on completion of the treatment.Results: Nearly all subjects displayed dry eye symptoms and signs at baseline. After the 8-week intervention, Korean red ginseng supplementation significantly improved the tear film stability and total Ocular Surface Disease Index score, as compared to placebo (p < 0.01).Conclusion: Korean red ginseng supplementation may provide an additional treatment option for dry eye and glaucoma patients using anti-glaucoma eye drops.