Comparative study of Korean White Ginseng and Korean Red Ginseng on efficacies of OVA-induced asthma model in mice – Accepted Manuscript

Abstract: Background: Korean ginseng is a well-known medicinal herb that has been widely used in traditional medicine to treat various diseases, including asthma. Ginseng can be classified as white or red ginseng, accordance to processing conditions. In this study, the authors compared the efficacies of these two ginseng types in mouse model of acute asthma.Methods: To produce the acute asthma model, BALB/c mice were sensitized with ovalbumin (OVA) and aluminum hydroxide, and then challenged with OVA. White and red ginseng extracts (WG and RG) were administered to mice orally. The influences of WG and RG on airway hyperresponsiveness (AHR), immune cell distributions in bronchoalveolar lavage fluid (BALF), and OVA-specific IgE, IgG1, and IgG2a in serum were investigated. Cytokine productions by lymphocytes isolated from peribronchial lymph nodes and histopathological changes also examined.Results: In OVA-sensitized mice, both WG and RG reduced AHR and suppressed immune cell infiltration in bronchoalveolar regions. BALF OVA-specific IgE levels were significantly lower in RG treated OVA-sensitized mice than in OVA-sensitized control group. WG and RG also suppressed inflammatory cytokine production by peribronchial lymphocytes. Histopathological findings showed reduced inflammatory cell infiltration and airway remodeling (e.g., epithelial hyperplasia) in WG and RG treated OVA mice than in OVA controls.Conclusion: In this study, WG and RG showed anti-asthmatic effects in an OVA-sensitized mouse model, and the efficacies of RG were found to be better than those of WG.