Ginsenoside compound K protects human umbilical vein endothelial cells against oxidized low-density lipoprotein-induced injury via inhibition of the NF-κB and p38, JNK MAPK pathways

Oxidized low-density lipoprotein (ox-LDL) caused vascular endothelial cell inflammatory response and apoptosis, acts as an important role in the development and progression of atherosclerosis (AS). Ginsenoside compound K (CK), a metabolite produced by hydrolysis of the ginsenoside Rb1, owns strong anti-inflammatory effects. However, whether CK protects ox-LDL-damaged endothelial cell and the potential mechanisms has not be elucidated.