The lepidopteran Asiatic corn borer (ACB), Ostriniafurnacalis (Guenee), has caused huge economic losses throughout the Asian-Western Pacific region. Usually, chemical pesticides are used to control, but excessive use of pesticides has caused great harm. Therefore, the inartificial ecotypic pesticides to ACB are extremely essential. In our previous study, we found that panaxadiol saponins (PDS) can effectively reduce the harm of ACB by causing antifeedant activity. So, it is necessary to reveal the biological molecular changes in ACB and the functionary mechanism of PDS.