Ginseng (Panax ginseng Meyer) is an invaluable medicinal plant containing various bioactive metabolites (e.g. ginsenosides). Due to its long cultivation period, ginseng is vulnerable to various biotic constraints. Biological control using endophytes is an important alternative to chemical control.
All posts by Young-Hwan Park, Ratnesh Chandra Mishra, Sunkyung Yoon, Hoki Kim, Changho Park, Sang-Tae Seo, Hanhong Bae
Identification of 20(S)-protopanaxadiol metabolites in human plasma and urine using UPLC-Q-TOF
20(S)-Protopanaxadiol (PPD), the aglycone part of 20(S)-protopanaxadiol ginsenosides, possesses antidepressant activity among many other pharmacological activities. It is currently undergoing clinical trial in China as an antidepressant.
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Non-saponin fraction of Korean Red Ginseng attenuates cytokine production via inhibition of TLR4 expression
Ginsenosides of Korean Red Ginseng extracts (RGE) and its saponin components suppress secretion of inflammasome-mediating cytokines while the non-saponin fraction (NS) of RGE oppositely stimulates cytokine secretion. Although direct exposure of NS to macrophages and mice induces cytokine production, oral administration of NS has not been studied in inflammasome-related disease model animals.
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Ginsenoside Rg1 activates ligand-independent estrogenic effects via rapid estrogen receptor signaling pathway
Ginsenoside Rg1 was shown to exert ligand-independent activation of estrogen receptor (ER) via mitogen-activated protein kinase (MAPK)-mediated pathway. Our study aimed to delineate the mechanisms by which Rg1 activates the rapid ER signaling pathways.
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Effect of Korean red ginseng in individuals exposed to high stress levels: A 6-week, double-blind, randomized, placebo-controlled trial
To investigate the neurobiological evidence supporting the adaptogenic effects of Korean red ginseng in reducing the harmful consequences of stress using a double-blind, placebo-controlled trial.
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Ginsenoside Rg3 suppresses mast cell-mediated allergic inflammation via MAPK signaling pathway
Ginsenoside Rg3 (G-Rg3) is the major bioactive ingredient of Panax ginseng and has many pharmacological effects including anti-adipogenic, anti-viral, and anti-cancer effects. However, the effect of G-Rg3 on mast cell-mediated allergic inflammation has not been investigated.
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Anti-melanogenesis and skin protective activities of Panax ginseng calyx ethanol extract
The anti-oxidant effects of Panax ginseng have been reported in several papers; however, little is known about the anti-melanogenesis effect, skin protective effect, and cellular mechanism of Panax ginseng, especially Panax ginseng calyx. To understand how an ethanol extract of P. ginseng berry calyx (Pg-C-EE) exerts skin protective effects we studied its activities in activated melanocytes and reactive oxygen species (ROS)-induced keratinocytes.
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Panax ginseng (Korea Red Ginseng) repairs diabetic sensorineural damage through promotion of the NGF pathway in diabetic zebrafish
Diabetic sensorineural damage is a complication of the sensory neural system, resulting from long-term hyperglycemia. Red ginseng (RG) has shown efficacy for treatment of various diseases, including diabetes mellitus; however, there is little research about its benefit for treating sensorineural damage. Therefore, we aim to evaluate RG efficacy in alloxan-induced diabetic neuromast (AIDN) zebrafish.
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Bioactivity-guided isolation of ginsenosides from Korean Red Ginseng with cytotoxic activity against human lung adenocarcinoma cells
Lung cancer is the leading cause of cancer-related death worldwide. In this study, we used a bioactivity-guided isolation technique to identify constituents of Korean Red Ginseng (KRG) with anti-proliferative activity against human lung adenocarcinoma cells.
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Production of ginsenoside aglycone (protopanaxatriol) and male sterility of transgenic tobacco co-overexpressing three Panax ginseng genes: PgDDS, CYP716A47, and CYP716A53v2
Protopanaxatriol is an aglycone of ginsenosides, which has high medicinal values. Production of protopanaxatriol (PPT) from natural ginseng plants requires artificial deglycosylation procedures of ginsenosides via enzymatic or chemo-physical treatments. Metabolic engineering could be an efficient technology for production of ginsenoside sapogenin. For PPT biosynthesis in P. ginseng, damarenediol-II synthase (PgDDS) and two cytochrome P450 enzymes (CYP716A47 and CYP716A53v2) are essentially required.
