Panax ginseng has long been used since ancient times based on Traditional Asian Medicine theory and clinical experiences, and currently, is one of the most popular herbs in the world. To date, most of the studies with P. ginseng have focused on specific mechanism of actions of individual constituents. However, in spite of many studies on the molecular mechanisms of P. ginseng, it still remains unclear how multiple active ingredients of P. ginseng interact with multiple targets simultaneously, giving the multidimensional effects on various conditions and diseases.
All posts by Sa-Yoon Park, Ji-Hun Park, Hyo-Su Kim, Choong-Yeol Lee, Hae-Jeung Lee, Ki Sung Kang, Chang-Eop Kim
Biosynthesis of rare 20()-protopanaxadiol/protopanaxatriol type ginsenosides through engineered with UDP-glycosyltransferase genes
Ginsenosides are known as the principal pharmacological active constituents in Panax medicinal plants such as Asian ginseng, American ginseng and Notoginseng. Some of the ginsenosides, especially the 20(R) isomers, are trace in natural source and difficult to be chemically synthesized. The present study provides an approach to produce such trace ginsenosides applying biotransformation through E.coli modified with relevent genes.
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Protective effects of Korean red ginseng against sub-acute immobilization stress-induced testicular damage in experimental rats
Excessive stress will cause varied physiological and psychological disorders including male reproductive problems. Here, we tend to investigate the protective effects of Korean red ginseng (Panax ginseng Meyer; KRG) against sub-acute immobilization stress-induced testicular damage in experimental rats.
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Preparative separation of minor saponins from leaves using biotransformation, macroporous resins and preparative high-performance liquid chromatography
Ginsenosides with fewer sugar moieties may exhibit better adsorptive capacity and more pharmacological activities.
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Effect of Korean red ginseng extracts on drug-drug interactions
Ginseng has been the subject of many experimental and clinical studies to uncover the diverse biological activities of its constituent compounds. It is a traditional medicine that has been used for its immunostimulatory, antithrombotic, antioxidative, anti-inflammatory, and anticancer effects. Ginseng may interact with concomitant medications and alter metabolism and/or drug transport, which may alter the known efficacy and safety of a drug; thus, the role of ginseng may be controversial when taken with other medications.
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Black Ginseng Activates Akt signaling, whereby Enhancing Myoblast Differentiation and Myotube Growth
Black ginseng (BG) has greatly enhanced pharmacological activities relative to white or red ginseng. However, the effect and molecular mechanism of BG on muscle growth has not been examined. In this study, we investigated whether BG could regulate myoblast differentiation and myotube hypertrophy.
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The effect of on the physiological properties of and on rhizospheric microbial diversity
Glomus intraradices is a species of arbuscular mycorrhizal fungi (AMF) that, as an obligate endomycorrhiza, can form mutually beneficial associations with plants. Panax ginseng is a famous traditional Chinese medicine; however, problems associated with ginseng planting, such as pesticide residues, reduce ginseng quality.
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Effect of Korean Red Ginseng extract on colorectal lung metastasis through inhibiting the epithelial-mesenchymal transition via TGF-β1/Smads signaling-mediated Snail/E-cadherin expression
In colorectal cancer (CRC), 40–60% of patients develop metastasis. The epithelial-mesenchymal transition (EMT) is a pivotal and intricate process that increases the metastatic potential of CRC. The aim of this study was to investigate the effect of Korean red ginseng extract (RGE) on colorectal metastasis through inhibiting of EMT and the metastatic abilities of CRC cells.
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A formulated red ginseng extract inhibits autophagic flux and sensitizes to doxorubicin-induced cell death
Ginseng is believed to have antitumor activity. Autophagy is largely a pro-survival cellular process that is activated in response to cellular stressors, including cytotoxic chemotherapy; therefore, agents that inhibit autophagy can be used as chemosensitizers in cancer treatment. We examined the ability of Korean red ginseng extract (RGE) to prevent autophagic flux and to make hepatocellular carcinoma (HCC) cells become more sensitive to doxorubicin.
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Microemulsion-based hydrogels for enhancing epidermal/dermal deposition of topically administered 20(S)-protopanaxadiol: and evaluation studies
20(S)-protopanaxadiol (20S-PPD) is a fully deglycosylated ginsenoside metabolite and has potent dermal anti-aging activity. However, due to its low aqueous solubility and large molecular size, a suitable formulation strategy is required to improve its solubility and skin permeability, thereby enhancing its skin deposition. Thus, we optimized microemulsion (ME)-based hydrogel (MEH) formulations for the topical delivery of 20S-PPD.
