Panax ginseng has long been used since ancient times based on Traditional Asian Medicine theory and clinical experiences, and currently, is one of the most popular herbs in the world. To date, most of the studies with P. ginseng have focused on specific mechanism of actions of individual constituents. However, in spite of many studies on the molecular mechanisms of P. ginseng, it still remains unclear how multiple active ingredients of P. ginseng interact with multiple targets simultaneously, giving the multidimensional effects on various conditions and diseases.