Diabetic neuropathy is one of the most devastating ailments occurring on peripheral nervous system. Neuropathic pain has been known to develop in about 30% of diabetics. Here, suppressive effect of GS-KG9 on neuropathic pain induced by streptozotocin (STZ) was examined.
All posts by Jee Youn Lee, Hae Young Choi, Chan Sol Park, Mi Kyung Pyo, Tae Young Yune, Go Woon Kim, Sung Hyun Chung
Enhanced Rg3 negatively regulates Th1 cell responses
Korean Red ginseng (KRG; Panax ginseng Meyer) is a widely used medicinal herb that is known to exert various immune modulatory functions. KRG and one of its purified components, ginsenoside Rg3, are known to possess anti-inflammatory activities. How they impact helper T cell-mediated responses is not fully explored. In this study, we attempted to evaluate the effect of Korean Red ginseng extract (KRGE) and ginsenoside-Rg3 on Th1 cell responses.
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High frequency somatic embryogenesis and plant regeneration of interspecific ginseng hybrid between and
Interspecific ginseng hybrid, Pgq (Panax ginseng × P. quenquifolius) has vigorous growth and produces larger roots than its both parents. However, the F1 progenies are complete male sterile. Plant tissue culture technology can be used to circumvent the issue and propagate the hybrid.
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Multicomponent assessment and ginsenosides conversions of L. roots before and after steaming by HPLC-MS
The structural conversions in ginsenosides induced by steaming or heating or acidic condition could improve red ginseng bioactivities significantly. In this paper, the chemical transformations of red American ginseng from fresh Panax quinquefolium L. under steaming were investigated and the possible mechanisms were discussed.
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Discovery of a new primer set for detection and quantification of in soils for ginseng cultivation
Korean ginseng is an important cash crop in Asian countries. However, plant yield is reduced by pathogens. Among the Ilyonectria radicicola-species complex, I. mors-panacis is responsible for root-rot and replant failure of ginseng in Asia. The development of new methods to reveal the existence of the pathogen before cultivation is started is essential. Therefore, a qRT-PCR method was developed to detect and quantify the pathogen in ginseng soils.
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Influence of organic acids and heat treatment on ginsenoside conversion
Heat treatments are applied to ginseng products in order to improve physiological activities through the conversion of ginsenosides, which are key bio-active components. During heat treatment, organic acids can affect ginsenoside conversion. Therefore, the influence of organic acids during heat treatment should be considered.
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Ginsenoside Rk1 ameliorates acetaminophen-induced hepatotoxicity in mice through inhibition of inflammation, oxidative stress, nitrative stress and apoptosis
Frequent overdose of acetaminophen (APAP) has become the major cause of acute liver injury (ALI). The present study was designed to evaluate the potential protective effects of ginsenoside Rk1 on APAP-induced hepatotoxicity and investigate the underlying mechanisms for the first time.
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Fermentation of red ginseng extract by the probiotic KCCM 11613P: Ginsenoside conversion and antioxidant effects
Ginsenosides, which are bioactive components in ginseng, can be converted to smaller size compounds for improvement of their pharmacological activities. The conversion methods include heating; acid, alkali, and enzymatic treatment; and microbial conversion. The aim of this study was to determine the bioconversion of ginsenosides in fermented red ginseng extract (FRGE).
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Ginsenoside Rb1 ameliorates cisplatin-induced learning and memory impairments
Ginsenoside Rb1 (Rb1), a dominant component from the extract of Panax ginseng root, exhibits neuroprotective functions in many neurological diseases. This study was intended to investigate whether ginsenoside Rb1 (Rb1) can attenuate cisplatin-induced memory impairments and explore the potential mechanisms.
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The protective Effect of Ultrasonication-Processed Ginseng Berry Extract on the D-GalN/LPS-induced Liver Injury Model in Rats
s: Acute hepatic failure (ALF) is life-threatening critical condition in which rapid deterioration of liver function and liver transplantation. Several studies have showed that Panax Ginseng Mayer has antidiabetic and hepatoprotective effect. However, the hepatoprotective effect of ginseng berry is still unveiled. In this study, we evaluated the hepatoprotective effects of ultrasonication processed ginseng berry extract (UGBE) on ALF model in rats.
