Roots of Withania somnifera (WS) are a celebrated medicinal ingredient in Ayurvedic and many other indigenous systems of medicine. The present study investigates the effect of the phytochemical composition of the extracts on their antioxidant and reducing activities.
All posts by Bhaskar Ganguly, Nirbhay Kumar, Abul H. Ahmad, Sunil K. Rastogi
GBCK25, fermented ginseng, attenuates cardiac dysfunction in high fat diet-induced obese mice
The fermentation of medicinal herbs facilitated by microbes is assumed to exert promising therapeutic efficacy on the absorption, bioavailability, and pharmacological effects by speed up the making or conversion of active constituents into their metabolites. We examined the cardioprotective potential of fermented ginseng, GBCK25, against high-fat diet (HFD)-induced metabolic and functional illnesses as following the essential analysis such as electrocardiographic parameters, alterations of body and organ weights, echocardiographic studies.
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Korean Red Ginseng mitigates spinal demyelination in a model of acute multiple sclerosis by down-regulating p38 MAPK and NF-κB signaling pathways
The potential therapeutic values of Korean Red Ginseng extract (KRGE) in autoimmune disorders of nervous system have not been fully investigated yet.
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ginseng exerts antidepressant-like effects by suppressing neuroinflammatory response and up-regulating Nrf2 signaling in the amygdala
Depression is one of the most commonly diagnosed neuropsychiatric diseases, but the underlying mechanism and medicine are not well-known. Although Panax (P.) ginseng has been reported to exert protective effects in various neurological studies, little information is available regarding its antidepressant effects.
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Gut microbiota-mediated pharmacokinetics of ginseng saponins
Orally administered ginsengs come in contact with the gut microbiota and their hydrophilic constituents, such as ginsenosides, are metabolized to hydrophobic compounds by gastric juice and gut microbiota: protopanxadiol-type ginsenosides are mainly transformed into compound K and ginsenoside Rh2, protopanaxatriol-type ginsenosides are to ginsenoside Rh1 and protopanaxatriol, and ocotillol-type ginsenosides to ocotillol. Although this metabolizing activity varies between individuals, the metabolism of ginsenosides to compound K by gut microbiota in individuals treated with ginseng is proportional to the area under the blood concentration curve (AUC) for compound K in their blood samples.
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Proteomic change by Korean Red Ginseng in the substantia nigra of a Parkinson's disease mouse model
Recent studies have shown that Korean Red Ginseng (KRG) successfully protects against dopaminergic neuronal death in the nigrostriatal pathway of a Parkinson’s disease (PD) mouse model induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration; however, the mechanism has yet to be identified. Therefore, in this study we used 2-dimensional electrophoresis (2-DE) to investigate the effects of KRG on the changes in protein expression in the substantia nigra (SN) of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated mice.
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Ginseng seed oil ameliorates hepatic lipid accumulation and
Despite the large number of studies on ginseng, pharmacological activities of ginseng seed oil (GSO) have not been established. GSO is rich in unsaturated fatty acids (UFAs), mostly oleic and linoleic acids. UFAs are known to exert therapeutic effects in non-alcoholic fatty liver disease (NAFLD). In this study, we investigated the protective effect and underlying mechanisms of GSO against NAFLD using in vitro and in vivo models.
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Functional role of ginseng-derived compounds in cancer
Ginseng is a natural product best known for its curative properties in diverse physiological processes such as cancers, neurodegenerative disorders, hypertension and maintenance of hemostasis in the immune system. In previous decades, there have been some promising studies into the pharmacology and chemistry of ginseng components and the relationship between their structure and function. The emerging use of modified ginseng and development of new compounds from ginseng for clinical studies have been a topic of study for many researchers.
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Alleviation of diabetic complications by ginsenoside Rg3-enriched Red Ginseng extract in Western diet-fed LDL mice
In this study, we precisely showed how the Rg3-enriched Red Ginseng extract (Rg3-RGE) lowers glucose, triglyceride, and low-density lipoprotein (LDL) levels in LDL-/- mice. Aspartate aminotransferase (AST/SGOT), alanine aminotransferase (ALT/SGPT), and steatohepatitis were found to be reduced, and atheroma formation was inhibited by Rg3-RGE.
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An investigation of Meyer growth promotion and the biocontrol potential of antagonistic bacteria against ginseng black spot
Ginseng black spot disease resulting from Alternaria panax Whuetz is a common soil-borne disease, with an annual incidence rate which is higher than 20% ∼ 30%. The bacterial strains with good antagonistic effect against A. panax are screened.
