In this study, we precisely showed how the Rg3-enriched Red Ginseng extract (Rg3-RGE) lowers glucose, triglyceride, and low-density lipoprotein (LDL) levels in LDL-/- mice. Aspartate aminotransferase (AST/SGOT), alanine aminotransferase (ALT/SGPT), and steatohepatitis were found to be reduced, and atheroma formation was inhibited by Rg3-RGE.