Ginsenoside Rg3 and arginine-fructose (Arg-Fru) are known as the hypotensive compounds of Panax ginseng, however, their efficacy on antihypertension has not been reported yet to our best knowledge. Thus, hypotensive components-enriched fraction of red ginseng (HCEF-RG) was prepared from fine root concentrate (FR) and their antihypertensive effects were investigated in spontaneously hypertensive rats (SHR).
All posts by Kyung Hee Lee, In Young Bae, Song I. Park, Jong-Dae Park, Hyeon Gyu Lee
Water-soluble ginseng oligosaccharides protect against scopolamine-induced cognitive impairment by functioning as an anti-neuroinflammatory agent
Panax ginseng roots have been used in Oriental traditional medicine for human health. Its main active components, such as saponins and polysaccharides, have been widely evaluated for treatment of diseases, but the secondary active components, such as oligosaccharides, were rarely studied. This study aimed to assess the impact of water-soluble ginseng oligosaccharides (WGOS), which are isolated from warm-water extract of Panax ginseng roots and its components were confirmed, on scopolamine-induced cognitive impairment in mice and its anti-neuroinflammatory mechanisms.
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Rapid separation and identification of 31 major saponins in Shizhu ginseng by UHPLC-ESI-MS/MS
Among ginseng strains, Shizhu ginseng is particular to China, mainly distributed in Manchu Automonous County of Kuandian, Liaoning Province, however, the identification of Shizhu ginseng was less developed.
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Anti-inflammatory and anti-fatigue effect of Korean Red Ginseng in patients with non-alcoholic fatty liver disease
Korea Red Ginseng (KRG) has been known as a natural product with anticarcinogenic and antioxidant effect. We evaluated the anti-fatigue effect of KRG in patients with non-alcoholic fatty liver disease (NAFLD).
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Role of microRNA-520h in 20(R)-ginsenoside-Rg3-mediated angiosuppression
Ginsenoside-Rg3, the pharmacologically active component of red ginseng, has been found to inhibit tumor growth, invasion, metastasis, and angiogenesis in various cancer models. Previously, we found that 20(R)-ginsenoside-Rg3 (Rg3) could inhibit angiogenesis. Since microRNAs (miRNAs) have been shown to affect many biological processes, they might play an important role in ginsenoside-mediated angiomodulation. In this study, we examined the underlying mechanisms of Rg3-induced angiosuppression through modulating miRNA expression.
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Variation in the number of nucleoli and incomplete homogenization of 18S rDNA sequences in leaves cells of the cultivated oriental ginseng, C.A. Meyer
Wild ginseng Panax ginseng Meyer is an endangered species of medicinal plants. In the present study, we analyzed variations within the rDNA cluster to gain insight into the genetic diversity of the oriental ginseng Panax ginseng at artificial plant cultivation.
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Black ginseng extracts ameliorates hypercholesterolemia in rats
Ginseng (Panax ginseng Meyer) is a well characterized medicinal herb listed in the classic oriental herbal dictionary as “Shin-nong-bon-cho-kyung”. Ginseng bears diverse pharmacologic and therapeutic properties. Black ginseng (BG, Ginseng Radix Nigra) is produced by repeatedly steaming fresh ginseng nine times. Studies of BG have shown that prolonged heat-treatment enhances the antioxidant activity with increased radical scavenging activity. Several recent studies have showed the effects of black ginseng on increased lipid profiles in mice.
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Protective effect of Korean Red Ginseng against chemotherapeutic drug induced premature catagen development assessed with human hair follicle organ culture model
Chemotherapy-induced alopecia (CIA) is one of the most distressing side effects for patients undergoing chemotherapy. This study evaluated the protective effect of Korean Red Ginseng (KRG) on CIA in a well-established in vitro human hair follicle organ culture model as it occurs in vivo.
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North American ginseng influences adipocyte-macrophage crosstalk regulation of inflammatory gene expression
Adipocyte-macrophage communication plays a critical role regulating white adipose tissue (WAT) inflammatory gene expression. Because WAT inflammation contributes to the development of metabolic diseases, there is significant interest to understand how exogenous compounds regulate adipocyte-macrophage crosstalk. Previous work showed that an aqueous extract of North American ginseng (Panax quinquefolius) had strong inflammo-regulatory properties in adipocytes. The present study examined if different ginseng extracts influence adipocyte-macrophage crosstalk, as well as WAT inflammatory gene expression.
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Beneficial effects of fermented black ginseng and its ginsenoside 20(S)-Rg3 against cisplatin-induced nephrotoxicity in LLC-PK1 cells
Nephrotoxicity is a common side effect of medications. Panax ginseng is one of the best-known herbal medicines and its individual constituents enhance renal function. Identification of its efficacy and mechanisms of action against drug-induced nephrotoxicity as well as the specific constituents mediating this effect have recently emerged as an interesting research area focusing on the kidney-protective efficacy of P. ginseng.
