Adipocyte-macrophage communication plays a critical role regulating white adipose tissue (WAT) inflammatory gene expression. Because WAT inflammation contributes to the development of metabolic diseases, there is significant interest to understand how exogenous compounds regulate adipocyte-macrophage crosstalk. Previous work showed that an aqueous extract of North American ginseng (Panax quinquefolius) had strong inflammo-regulatory properties in adipocytes. The present study examined if different ginseng extracts influence adipocyte-macrophage crosstalk, as well as WAT inflammatory gene expression.