In present study, metabolite profiles of ginsenosides Rk1 and Rg5 from red ginseng or red notoginseng in zebrafish were qualitatively analyzed with the Ultraperformance Liquid Chromatography/Quadrupole -Time-of-Flight Mass Spectrometry, and then we put forward the possible metabolic pathways.
All posts by Wenwen Shen, Yingjie Wei, Daoquan Tang, Xiaobin Jia, Bin Chen
Anti-aging effects of the mixture of and in human dermal fibroblasts and healthy human skin
Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to up regulation of MMP-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of Panax ginseng Meyer and Crataegus pinnatifida (GC) would have protective effects against skin aging.
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Comparative analysis of the transcriptomes and primary metabolite profiles of adventitious roots of five cultivars
Various Panax ginseng cultivars exhibit range of diversity for morphological and physiological traits. However there is less study on diversity of metabolic profiles and genetic background to understand the complex metabolic pathway in ginseng.
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anti-oxidative and anti-inflammatory effects of BIOGF1K, compound K-rich fraction, prepared from
BIOGF1K, a compound K-rich fraction prepared from the root of Panax ginseng is widely applied in cosmetic purpose in Korea. We firstly investigated the functional mechanisms of anti-inflammatory and anti-oxidative activities of BIOGF1K by discovering target enzymes through various molecular studies.
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The effect of Korean Red Ginseng extract on rosiglitazone-induced improvement of glucose regulation in diet-induced obese mice
Korean Red Ginseng extract (KRG, Panax ginseng Meyer) and its constituents have been used for the treatment of diabetes. However, it remains unclear whether KRG can enhance the glucose-lowering action of rosiglitazone (ROSI), a peroxisome proliferator-activated receptor gamma synthetic activator, in diet-induced obese mice.
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Biotransformation of major ginsenosides in ginsenoside model culture by lactic acid bacteria
Some differences have been reported in the biotransformation of ginsenosides, probably due to the types of materials used such as ginseng, enzymes, and microorganisms. Moreover, most microorganisms used for transforming ginsenosides do not meet food-grade standards. We investigated the statistical conversion rate of major ginsenosides in ginsenosides model culture (GMC) during fermentation by lactic acid bacteria (LAB) in order to estimate possible pathways.
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Rapid characterization of ginsenosides in the roots and rhizomes of by UPLC−DAD−QTOF−MS/MS and simultaneous determination of 19 ginsenosides by HPLC–ESI–MS
Ginsenosides are the characteristic and principal components which manifest a variety of the biological and pharmacological activities of the roots and rhizomes of Panax ginseng (GRR). This study was carried out to qualitatively and quantitatively determine the ginsenosides in the cultivated and forest GRR.
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Ginsenoside Rd alleviates mouse acute renal ischemia/reperfusion injury by modulating macrophage phenotype
Ginsenoside Rd (GSRd), main components of the root of Panax ginseng, exhibit anti-inflammation functions and decrease infarct size in many injuries and ischemia diseases like focal cerebral ischemia. M1 Macrophages are regarded as one of the key inflammatory cells having functions for disease progression.
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Development of a SNP Marker for Specific Authentication of Korean ginseng’s ( Meyer) New cultivar “G-1”
Korean ginseng (Panax ginseng) one of the well-known medicinal plant of Oriental medicine that is still in practice. A total of 11 Korean ginseng cultivars with unique features to Korean ginseng have been developed until now based on pure line selection method. Among them, a new cultivar namely G-1 with different agricultural traits related to yield and content of ginsenosides was developed in 2012.
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Microbial conversion of major ginsenosides in ginseng total saponins by endophytes
In this study, we screened and identified an endophyte JG09 having strong biocatalytic activity for ginsenosides from Platycodon grandiflorum (P. grandiflorum), converted ginseng total saponins and ginsenoside monomers, determined the source of minor ginsenosides and the transformation pathways, and calculated the maximum production of minor ginsenosides for the conversion of ginsenoside Rb1 to assess the transformation activity of endophyte JG09.
