Panax ginseng Meyer, belonging to the genus Panax of the family Araliaceae, is known for its human immune system-related effects such as immune-boosting effects. Ginseng polysaccharides (GPs) are the responsible ingredient of ginseng in immunomodulation, which are classified as acidic and neutral GPs. Although GPs participate in various immune reactions including the stimulation of immune cells and production of cytokines, the precise function of GPs together with its potential receptor(s) and their signal transduction pathways have remained largely unknown.
All posts by So Hee Loh, Jin-Yeon Park, Eun Hee Cho, Seung-Yeol Nah, Young-Sun Kang
Determination of ginsenosides in Asian and American Ginsengs by liquid chromatography-quadrupole/time of flight-mass spectrometry: assessing variations based on morphological characteristics
Asian ginseng and American ginseng are functional food that share a close genetic relationship and are well-known worldwide. This article aims to investigate the correlation between morphological characteristics and the inherent quality of Asian and American ginsengs.
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Ginsenoside Rg1 suppresses early stage of adipocyte development via activation of CHOP10 in 3T3-L1 and attenuates fat accumulation in high fat diet-induced obese zebrafish
Ginsenoside Rg1 is a class of steroid glycoside and triterpene saponin in Panax ginseng. Many studies suggest that Rg1 suppress adipocyte differentiation in 3T3-L1. However, the detail molecular mechanism of Rg1 on adipogenesis in 3T3-L1 has still not been fully understood yet.
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Discrimination of Korean ginseng ( Meyer) cultivar Chunpoong and American ginseng () using the gene
Korean ginseng (Panax ginseng) is one of the most important medicinal plants in the Orient. Among nine cultivars of P. ginseng, Chunpoong commands a much greater market value and has been planted widely in Korea. Chunpoong has superior quality “Chunsam (1st grade ginseng) when made into red ginseng.
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Effect of Red Ginseng on Cytochrome P450 and P-glycoprotein Activities in Healthy Volunteers
We evaluated the drug interaction profile of red ginseng (RG) with respect to the activities of major cytochrome P450 (CYP) enzymes and the drug transporter P-glycoprotein (P-gp) in healthy Korean volunteers.
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VASP-phosphorylation by ginsenoside Ro inhibits fibrinogen binding to αIIb/β in thrombin-induced human platelets
Glycoprotein IIb/IIIa (αIIb/β3) is involved in platelet adhesion, and triggers a series of intracellular signaling cascade, leading to platelet shape change, granule secretion and clot retraction. In this study, we evaluated the effect of ginsenoside Ro (G-Ro) on the binding of fibrinogen to αIIb/β3.
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Identification of mountain cultivated ginseng and cultivated ginseng using UPLC–oa-TOF MSE with a Multivariate Statistical Sample Profiling Strategy
The mountain cultivated ginseng (MCG) and cultivated ginseng (CG) both belong to the Panax ginseng, which have similar ingredients. However, their pharmacological activities are obviously different due to the significant differences in growth environment.
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Ginsenoside Rb1 and compound K improve insulin signaling and inhibit ER stress-associated NLRP3 inflammasome activation in adipose tissue
This study was designed to investigate whether ginsenoside Rb1 (Rb1) and compound K (CK) ameliorated insulin resistance by suppressing endoplasmic reticulum stress (ER stress)-induced inflammation in adipose tissue.
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The Change of ginsenoside composition in the Red ginseng () by the ultrasonication process
The result of USRG-12 indicates that the ultrasonication processed Red ginseng extracts (at 100°C) treated for 12 hrs produced the highest amount of ginsenoside Rg3 (0.803%), Rg5 (0.167%) and Rk1 (0.175%).
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In vitro and in vivo evaluation of Tissue-cultured mountain ginseng on penile erection
Progressed tissue culture techniques have allowed to easily obtain mass product of Tissue-Cultured Mountain Ginseng over 100 years old (TCMG-100). We investigated the effects of TCMG-100 extract on erectile function by in vitro and in vivo studies.
