Korean ginseng (Panax ginseng) plays an anti-inflammatory role in variety of inflammatory diseases such as gastritis, hepatitis, and colitis. However, inflammation-regulatory activity of the calyx of the P. ginseng berry has not been thoroughly evaluated. To understand whether the calyx portion of the P. ginseng berry is able to ameliorate inflammatory processes, an ethanolic extract of P. ginseng berry calyx (Pg-C-EE) was prepared, and LPS-activated macrophages and HEK293 cells transfected with inflammation-regulatory proteins were employed to test the anti-inflammatory action of Pg-C-EE.
Chronic dietary ginseng extract administration ameliorates antioxidant and cholinergic systems in the brains of aged mice
Black ginseng has a more potent biological activity than non-steamed ginseng has. We investigated the effects of long-term intake of dietary black ginseng extract (BG) on antioxidant activity in aged mice. We also compared the effects of BG on cognitive deficits with those of white ginseng extract (WG) and red ginseng extract (RG).
Share this:
C/N/O/S Stable Isotopic and Chemometric Analyses for Determining the Geographical Origin in of Cultivated in Korea
The geographical origin of Panax ginseng Meyer, a valuable medicinal plant, is important to both ginseng producers and consumers in the context of economic profit and human health benefits. We, therefore, aimed to discriminate between the cultivation regions of ginseng using the stable isotope ratios of C, N, O, and S, which are abundant bio-elements in living organisms.
Share this:
Ginsenosides from Korean Red Ginseng ameliorate lung inflammatory responses: Inhibition of the MAPKs/NF-κB/c-Fos pathways
Korean Red Ginseng (steamed and dried white ginseng, Panax ginseng Meyer) is well-known for enhancing vital energy and immune capacity, and inhibiting cancer cell growth. Some clinical studies also demonstrated a therapeutic potential of ginseng extract for treating lung inflammatory disorders. This study was carried out to establish the therapeutic potential of ginseng saponins on the lung inflammatory response.
Share this:
Ginsenoside Rg1 from Enhances Myoblast Differentiation and Myotube Growth in C2C12 Myoblasts
Ginsenoside Rg1 belongs to protopanaxatriol-type ginsenosides and has diverse pharmacological activities. In this report, we investigated whether Rg1 could upregulate muscular stem cell differentiation and muscle growth.
Share this:
Effect of polysaccharides from a Korean ginseng berry on the immunosenescence of aged mice
Korean ginseng has been widely evaluated to treat human diseases; however, most studies on Korean ginseng have focused on its root. In this study, polysaccharides [acidic-polysaccharide-linked glycopeptide (APGP) extracted with 90% ethanol and hot water] were prepared from Korean ginseng berries, and their effect on immunosenescence was explored.
Share this:
Korean Red Ginseng extract and ginsenoside Rg3 have anti-pruritic effects on chloroquine-induced itch by inhibition of -mediated pathway
It was previously found that Korean Red Ginseng water extract (KRGE) inhibits histamine-induced itch signaling pathway in peripheral sensory neurons. Thus, in the present study, it was investigated whether KRGE may inhibit another distinctive itch pathway induced by chloroquine (CQ), a representative histamine-independent pathway mediated by MrgrpA3 and TRPA1.
Share this:
Ginsenoside Rh2 epigenetically regulates cell-mediated immune pathway to inhibit proliferation of MCF-7 breast cancer cells
Ginsenoside Rh2 has been known to enhance the activity of immune cells as well as to inhibit the growth of tumor cells. Although the repertoire of genes regulated by Rh2 is well-known in many cancer cells, the epigenetic regulation has yet to be determined, especially for comprehensive approaches to detect methylation changes.
Share this:
Influence of phytochemical composition on antioxidant and reducing activities of Indian ginseng [ (L.) Dunal] root extracts
Roots of Withania somnifera (WS) are a celebrated medicinal ingredient in Ayurvedic and many other indigenous systems of medicine. The present study investigates the effect of the phytochemical composition of the extracts on their antioxidant and reducing activities.
Share this:
GBCK25, fermented ginseng, attenuates cardiac dysfunction in high fat diet-induced obese mice
The fermentation of medicinal herbs facilitated by microbes is assumed to exert promising therapeutic efficacy on the absorption, bioavailability, and pharmacological effects by speed up the making or conversion of active constituents into their metabolites. We examined the cardioprotective potential of fermented ginseng, GBCK25, against high-fat diet (HFD)-induced metabolic and functional illnesses as following the essential analysis such as electrocardiographic parameters, alterations of body and organ weights, echocardiographic studies.
