Ginsenosides are active components of Panax ginseng that exert various health benefits including kidney protection effect. The medicinal activity of ginsenosides can be enhanced by modulating their stereospecificity by heat processing. Ginsenosides Rk2 and Rh3 represent positional isomers of the double bond at C-20(21) or C-20(22).
Korean Red Ginseng exhibits no significant adverse effect on disease activity in patients with rheumatoid arthritis: A randomized, double-blind, crossover study
Panax ginseng is a well-known immune modulator, and there is concern that its immune-enhancing effects may negatively affect patients with rheumatoid arthritis (RA) by worsening symptoms or increasing the risk of adverse effects from other drugs. In this randomized, crossover clinical trial, we evaluated the impact of Korean Red Ginseng (KRG) on disease activity and safety in RA patients.
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The molecular signaling of ginsenosides Rb1, Rg1, Rg3 and their mode of actions
Ginseng has gained its popularity as an adaptogen since ancient days due to their triterpenoid saponins, known as ginsenosides. These triterpenoid saponins are unique and classified as protopanaxatriol and protopanaxadiol saponins based on their glycosylation patterns. It shows many protective roles in humans and is of intense research to understand their efficacy at the molecular aspect in various disorders. Ginsenoside Rb1 and Rg1 are the most abundant ginsenosides present in ginseng roots, and they confer the pharmacological property of it while ginsenoside Rg3 is abundantly present in the Korean Red Ginseng (KRG) preparation, which is highly known for its anti-cancer effect.
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Subacute oral toxicity and bacterial mutagenicity study of Korean red ginseng oil
Red ginseng oil (RGO) is produced by supercritical CO2 extraction of secondary products derived from Korean red ginseng extract. As the use of RGO has increased, product safety concerns have become more important.
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Qualitative and quantitative analysis of the saponins in leaves using ultra performance liquid chromatography coupled with time-of-flight tandem mass spectrometry and high performance liquid chromatography coupled with UV detector
Panax notoginseng leaves (PNL) exhibit the extensive activities, but few analytical methods were established to exclusively determine the dammarane triterpene saponins in PNL.
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The effect of red ginseng and ginseng leaves on the substance and energy metabolism in hypothyroidism rats
Recent studies revealed that the property of traditional Chinese medicine is mostly associated with the substance and energy metabolism. Our study was to compare the effect of red ginseng (warm property) and ginseng leaves (cold property) on the substance and energy metabolism in hypothyroidism rats.
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Effects of processing method on the pharmacokinetics and tissue distribution of orally administered ginseng
The use of different methods for the processing of ginseng can result in alterations in its medicinal properties and efficacy. White ginseng (WG), frozen ginseng (FG), and red ginseng (RG) are produced using different methods. WG, FG, and RG possess different pharmacological properties.
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Cold-water extract of Korean Red Ginseng exhibits potent inhibitory effects against cholesteryl ester transfer protein activity and fructose-mediated glycation along with lipid-lowering activity in hyperlipidemic zebrafish
Red Ginseng (RG) is widely used to treat complications of diabetes and atherosclerosis due to its antioxidative and anti-inflammatory activities.
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Discovery, semi-synthesis, biological activities and metabolism of Ocotillol-type saponins
Ocotillol-type saponins are one kind of tetracyclic triterpenoids, sharing a tetrahydrofuran ring. Natural ocotillol-type saponins have been discovered in Panax. quinquefolius L., Panax japonicus, Hana Mina, and Vietnamese ginseng. In recent years, the semi-synthesis of 20(S/R)-ocotillol-type saponins has been reported. The biological activities of ocotillol-type saponins include neuroprotective effect, anti-myocardial ischemia, anti-inflammatory, anti-bacterial, anti-tumor etc. Owing to characteristics of their chemical structure, pharmacological actions and the stereoselective activity on anti-myocardial ischemia, ocotillol-type saponins are subjected to extensive consideration.
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Ginsenoside Rg3-enriched Red Ginseng extract inhibits platelet activation and thrombus formation
Korean Red Ginseng has been used for several decades to treat many diseases, enhancing both immunity and physical strength. Previous studies have documented the therapeutic effects of ginseng, including its anti-cancer, anti-aging, and anti-inflammatory activities. These activities are mediated by ginsenosides present in the ginseng plant. Ginsenoside Rg3, an effective compound from Red Ginseng, has been shown to have anti-platelet activity in addition to its anti-cancer and anti-inflammatory activities.
