Cancer is emerged as a major health problem globally consequent to increase longevity of the population, changing the environment and life style. Chemoprevention is a new and promising strategy against cancer burden. Recently, some natural products have been identified for their chemopreventive activity for the reduction in cancer incidences. Ginseng is known for its potential to treat various ailments in human beings. The present study was designed to explore the anticancer and anti-oxidative potential of Panax ginseng against chemical induced skin carcinogenesis in mammals.
Tag Archives: science
Administration of red ginseng ameliorates the memory decline in aged mice
It has been known that ginseng can be applied as a potential nutraceutical for memory impairment, however experiments with animals of old age are few.
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Red Ginseng extract blocks histamine-dependent itch by inhibition of H1R/TRPV1 pathway in sensory neurons
Korean Red Ginseng – a steamed root of Panax ginseng Meyer – has long been used as a traditional medicine in Asian countries. Its anti-pruritic effect was recently found, but no molecular mechanisms were revealed. Thus, the current study focused on determining the underlying molecular mechanism of Korean Red Ginseng extract (RGE) against histamine-induced itch at the peripheral sensory neuronal level.
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Effects of Korean Red Ginseng extract on busulfan-induced dysfunction of male reproductive systems
Anti-cancer agents induce a variety of adverse effects when they are administered to cancer patients. Busulfan is a known anti-leukemia agent. When administered for treatment of leukemia in young patients, busulfan could cause damage of the reproductive system as one of its adverse effects, resulting in male sterility.
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Anti-melanogenic effect of ginsenoside Rg3 through ERK-mediated inhibition of microphthalmia-associated transcription factor
Panax ginseng has been used to prolong longevity and is believed to be useful for skin beauty. Ginsenosides are the most active components isolated from ginseng, and ginsenoside Rg3 (G-Rg3) in particular has been demonstrated to possess antioxidative, anti-tumorigenic, and anti-inflammatory effects. The aim of this study was to examine the ability of G-Rg3 to inhibit melanogenesis.
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American ginseng significantly reduced the progression of high-fat diet enhanced colon carcinogenesis in mice
Colorectal cancer (CRC) is a leading cause of death worldwide. Chronic gut inflammation is recognized as a risk factor for tumor development, including CRC. American ginseng is a very commonly used ginseng species in the West.
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Chemical diversity of ginseng saponins from
Ginseng, a perennial plant belonging to the genus Panax of Araliaceae, is well known for its medicinal properties that help alleviate pathological symptoms, promote health, and prevent potential diseases. Among the active ingredients of ginseng are saponins, most of which are glycosides of triterpenoid aglycones. So far, numerous saponins have been reported as components of Panax ginseng, also known as Korean ginseng. Herein, we summarize available information about 113 saponins related to Panax ginseng; more than 80 of them are isolated from raw or processed ginseng, and the others are acid/base hydrolysates, semi-synthetic saponins, or metabolites.
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Preparation of minor ginsenoside C-Mc, C-Y, F2 and C-K from American ginseng PPD-ginsenoside using special ginsenosidase type-I from g.848
Minor ginsenosides, low content in ginseng, have higher pharmacological activities. To obtain minor ginsenosides, the biotransformation of American ginseng PPD-ginsenoside was studied using special ginsenosidase type-I from Aspegillus niger g.848. The methods of DEAE-cellulose and PAGE were used in enzyme purification, TLC and HPLC were used in enzyme hydrolysis and kinetics; crude enzyme was used in minor ginsenoside preparation from PPD-ginsenoside; the products were separated with silica-gel-column, and recognised by HPLC and NMR.
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Induction of systemic resistance in against by native HK34
Korean ginseng (Panax ginseng Meyer) is a perennial herb prone to various root diseases with Phytophthora cactorum as one of the most dreaded disease causing foliar blight and root rot. Although chemical pesticides are available for disease control, attention has been shifted to viable, eco-friendly and cost-effective biological means like plant growth promoting rhizobacteria (PGPR) for control of diseases.
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Ginseng total saponins attenuates myocardial injury via anti-oxidative and anti-inflammatory properties
Ginseng total saponin (GTS) has been shown to possess various ginsenosides. These ginsenosides is widely used for treating cardiovascular diseases in Asian communities. The aim of this study was to study the effects of GTS on cardiac injury after the global ischemia and reperfusion (I/R) in isolated guinea pig hearts.
