Cancer is emerged as a major health problem globally consequent to increase longevity of the population, changing the environment and life style. Chemoprevention is a new and promising strategy against cancer burden. Recently, some natural products have been identified for their chemopreventive activity for the reduction in cancer incidences. Ginseng is known for its potential to treat various ailments in human beings. The present study was designed to explore the anticancer and anti-oxidative potential of Panax ginseng against chemical induced skin carcinogenesis in mammals.