Intracellular Ca2+ ([Ca2+]i) is platelet aggregation-inducing molecule. Therefore, understanding the inhibitory mechanism of [Ca2+]i mobilization is very important to evaluate the antiplatelet effect of a substance. This study was carried out to understand the Ca2+-antagonistic effect of total saponin from Korean red ginseng (KRG-TS).
Monthly Archives: March 2015
Photosynthesis rates, growth and ginsenoside contents of 2-year-old grown at different light transmission rates in a greenhouse
Ginseng is a semi-shade perennial plant cultivated at sloping, sun-shading area in Korea. Recently, due to air-environmental stress and various fungal diseases, greenhouse cultivation has been suggested as an alternative. However, the optimal light transmission rate (LTR) in the greenhouse has not been established.
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Accumulation characteristics and correlation analysis of five ginsenosides in Panax ginseng from different cultivation regions and ages
Ginseng (the roots of Panax ginseng C. A. Meyer) is a well-known traditional oriental medicine and now it is widely used as a health food. It contains several types of ginsenosides, which are considered as the major active medicinal components of ginseng. It has recently been reported that qualitative and quantitative properties of ginsenosides found in ginseng may differ, depending on cultivation regions, grown ages, species and so on. So it is necessary to study the variation respect to cultivation ages and regions of the main ginsenosides in ginseng.
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Insulin sensitivity improvement of fermented Korean Red Ginseng () mediated by insulin resistance hallmarks in old aged mice
The biological actions of various ginseng extracts have been studied for treating obesity and diabetes mellitus. However, few studies have evaluated the effects of fermented Korean red ginseng (Panax ginseng Meyer) on metabolic syndrome. The present study evaluated the anti-obesity and anti-diabetic effects of fermented red ginseng (FRG) on old aged obese leptin-deficient (B6.V-Lepob, “ob/ob”) mice.
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Inhibitory mechanism of Korean Red Ginseng on GM-CSF expression in UVB-irradiated keratinocytes
Ultraviolet (UV)-irradiated keratinocytes secrete various proinflammatory cytokines. UV-induced skin damage is mediated by growth factors and proinflammatory cytokines such as granulocyte macrophage colony stimulating factor (GM-CSF). In a previous study, we found that saponin of Korean red ginseng (SKRG) decreased the expression of GM-CSF in UVB-irradiated SP-1 keratinocytes. In this study, we tried to find the inhibitory mechanism of SKRG on UVB-induced GM-CSF expression in SP-1 keratinocytes.
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Anti-proliferative activity of decoction products in HeLa cells
This study aims to investigate the effect of decoction process on the change of ginsenosides and relation with anti-proliferative effect in HeLa cells.
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Effect of Korean Red Ginseng treatment on the gene expression profile of diabetic rat retina
Korean Red Ginseng (KRG) is an herbal medicine used in Asian countries and is very popular for its beneficial biological properties. Diabetes mellitus (DM) and its complications are rapidly becoming a global public health concern. The literature on transcriptional changes induced by KRG in rat models of diabetic retinopathy is limited. Considering these facts, we designed this study to determine whether retinopathy-associated genes are altered in DM rat retinas and whether the induced changes are reversed by KRG.
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Effect of Korean Red Ginseng treatment on the gene expression profile of diabetic rat retina
Korean Red Ginseng (KRG) is an herbal medicine used in Asian countries and is very popular for its beneficial biological properties. Diabetes mellitus (DM) and its complications are rapidly becoming a global public health concern. The literature on transcriptional changes induced by KRG in rat models of diabetic retinopathy is limited. Considering these facts, we designed this study to determine whether retinopathy-associated genes are altered in DM rat retinas and whether the induced changes are reversed by KRG.
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Kinetic study for the optimization of ginsenoside Rg3 production by heat treatment of ginsenoside Rb1
Ginsenoside Rg3 is a promising anticancer agent. It is usually produced by heat treating ginseng, in which ginsenoside Rb1 is the major ginsenoside. A kinetic study was conducted to optimize ginsenoside Rg3 production by the heat treatment of ginsenoside Rb1.
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Ginsenoside Re inhibits pacemaker potentials via ATP sensitive K channels and a cGMP/nitric oxide-dependent pathway in cultured interstitial cells of Cajal from mouse small intestine
Ginseng belongs to the genus Panax and its main active ingredients are called ginsenosides. Interstitial cells of Cajal (ICCs) are the pacemaker cells of the gastrointestinal (GI) tract. To understand the effects of ginsenoside Re (GRe) on GI motility, the authors investigated its effects on the pacemaker activities of ICCs of the murine small intestine.
