Ginsenoside Re inhibits pacemaker potentials via ATP sensitive K channels and a cGMP/nitric oxide-dependent pathway in cultured interstitial cells of Cajal from mouse small intestine

Ginseng belongs to the genus Panax and its main active ingredients are called ginsenosides. Interstitial cells of Cajal (ICCs) are the pacemaker cells of the gastrointestinal (GI) tract. To understand the effects of ginsenoside Re (GRe) on GI motility, the authors investigated its effects on the pacemaker activities of ICCs of the murine small intestine.