Anti-aging effects of the mixture of and in human dermal fibroblasts and healthy human skin

Human skin undergoes distinct changes throughout the aging process, based on both intrinsic and extrinsic factors. In a process called photoaging, UVB irradiation leads to up regulation of MMP-1, which then causes collagen degradation and premature aging. Mixtures of medicinal plants have traditionally been used as drugs in oriental medicine. Based on the previously reported antioxidant properties of Panax ginseng Meyer and Crataegus pinnatifida, we hypothesized that the mixture of Panax ginseng Meyer and Crataegus pinnatifida (GC) would have protective effects against skin aging.