Korean ginseng, Panax ginseng Meyer (P. ginseng), has been used as a traditional oriental medicine to treat illness and promote health for several thousand years. Ginsenosides are the main constituents for the pharmacological effects of P. ginseng. Since several ginsenosides, including G-Rg3 and G-Rp1, was reported the anti-platelet activity, here we investigated the ability of G-Rp4 to modulate ADP-induced platelet aggregation. The ginsenoside Rp4 (G-Rp4), a similar chemical structure of ginseoside Rp1, was prepared from G-Rg1 by chemical modification.

The present study investigated the effect of ginseng berry hot water extract (GBx) on blood flow via regulation of lipid metabolites and blood coagulation in rats fed a high-fat diet (HFD).