Red-skin root disease has seriously decreased the quality and production of Panax ginseng (ginseng).
Effects of Korean ginseng berry on skin anti-pigmentation and anti-aging via FoxO3a activation
The ginseng berry has various bioactivities, including anti-diabetic, anti-cancer, anti-inflammatory, and anti-oxidative properties. Moreover, we have revealed that the active anti-aging component of the ginseng berry, syringaresinol, has the ability to stimulate longevity via gene activation. Despite the many known beneficial effects of ginseng, its effects on skin aging are poorly understood. In this study, we investigated the effects of ginseng and the ginseng berry on one of the skin aging processes, melanogenesis and age-related pigment lipofuscin accumulation, to elucidate the mechanism of action with respect to anti-aging.
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Identification of ginseng root using quantitative X-ray microtomgraphy
The use of X-ray phase-contrast microtomography (XPCMT) for the investigation of Chinese medicinal materials (CMMs) is advantageous for its nondestructive, in-situ and three-dimensional (3D) quantitative imaging properties.
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In vitro grown thickened taproots, a new type of soil transplanting source in Panax ginseng
The low survival rate of in vitro regenerated Panax ginseng plantlets after transfer to soil is the main obstacle for the successful micropropagation and molecular breeding. In most cases, young plantlets converted from somatic embryos are transferred to soil.
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Protective effect of Korean Red Ginseng against FK-506-induced damage in LLC-PK1 cells
Compound FK506 is an immunosuppressant agent that is frequently used to prevent rejection of solid organs upon transplant. However, nephrotoxicity due to apoptosis and inflammatory response mediated by FK506 limit its usefulness. In this study, the protective effect of Korean Red Ginseng (KRG) against FK-506-induced damage in LLC-PK1 pig kidney epithelial cells was investigated.
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Inhibitory effects of ginsenosides on bFGF-induced melanocyte proliferation
UVB-exposed keratinocytes secrete various paracrine factors. Among these factors, basic fibroblast growth factor (bFGF) stimulates the proliferation of melanocytes. Ginsenosides, the major active compounds of ginseng, are known to have broad pharmacological effects. In this study, we examined the anti-proliferative effects of ginsenosides on bFGF-induced melanocyte proliferation.
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Processed Panax ginseng, sun ginseng, inhibits the differentiation and proliferation of 3T3-L1 preadipocytes and fat accumulation in C. elegans
Heat processed ginseng, Sun ginseng (SG), has been reported to have improved therapeutic properties compared to raw forms, such as increased efficiencies of anti-diabetic, anti-inflammatory, and anti-hyperglycemic effects. The aim of the present study was to investigate the anti-obesity effects of SG through the suppression of cell differentiation and proliferation of mouse 3T3-L1 preadipocyte cells and the lipid accumulation in Caenorhabditis elegans (C. elegans).
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Induction of FOXO3a and apoptosis by a standardized ginsenoside formulation KG-135 is potentiated by autophagy blockade in A549 human lung cancer cells
KG-135, a standardized formulation enriched with Rk1, Rg3, Rg5, had been shown to inhibit various types of cancer cells but the underlying mechanisms are not fully understood. We explore its effects in A549 human lung cancer cells to investigate the induction of FOXO3a and autophagy.
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Inhibition of hypoxia-induced cyclooxygenase-2 by Korean red ginseng is dependent on peroxisome proliferator-activated receptor gamma
Korean Red Ginseng (KRG) is a traditional herbal medicine made by steaming and drying fresh ginseng. It strengthens the endocrine and immune systems to ameliorate various inflammatory responses. The cyclooxygenase-2 (COX-2)/prostaglandin E2 pathway has important implications for inflammation responses and tumorigenesis. Peroxisome proliferator-activated receptor gamma (PPARγ) is a transcription factor that regulates not only adipogenesis and lipid homeostasis but also angiogenesis and inflammatory responses.
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Optimal light for the greenhouse culture of American ginseng seedlings
Three greenhouse experiments with American ginseng seedlings growing under light levels from 4.8 to 68% showed a quadratic response for root dry weight giving an optimal root dry weight of 239 mg (range 160 to 415) at an optimal light level of 35.6% (range 30.6 to 43.2).
