Panax ginseng Meyer has been cultivated because of its medicinal effects on immune system, blood pressure, and cancer. Major ginsenosides in fresh ginseng are converted to minor ginsenosides by structural changes such as hydrolysis and dehydration. The transformed ginsenosides are generally more bioavailable and bioactive than the primary ginsenosides. In this study, therefore, hydrothermal processing was applied to ginseng preparation to increase the yields of the transformed ginsenosides, such as 20(S)-Rg3, Rk1, and Rg5, and enhance antioxidant activities in an effective way.
Pectinase-treated protects against chronic intermittent heat stress-induced testicular damage by modulating hormonal and spermatogenesis-related molecular expression in rats
Elevated testicular temperature disrupts spermatogenesis and causes infertility. In the present study, the protective effect of enzymatically biotransformed Panax ginseng Meyer by pectinase (GINST) against chronic intermittent heat stress-induced testicular damage in rats was investigated.
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HPLC analysis of phytosterols in the roots of grown under different conditions
The plant of Panax ginseng has been used as an herbal medicine. Phytosterols of P. ginseng with inhibitory effects on inflammation-related factors in HepG2 cells have been reported.
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Using Reverse Docking to Identify Potential Targets for Ginsenosides
Ginsenosides are the main ingredients of ginseng, which, in traditional Eastern medicine, has been claimed to have therapeutic values for many diseases. In order to verify the effects of ginseng which have been empirically observed we utilized reverse docking method to screen for target proteins that are linked to specific diseases.
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Ginsenoside Rg12, a new dammarane-type triterpene saponin from root
Panax ginseng has been used as Korean medicine for various diseases. It has antioxidant, hypotensive, sedative, analgesic, and endocrine activities. Dammarane-type triterpenes from the plant have various beneficial effects.
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Non-saponin fractions of Korean Red Ginseng extracts prime activation of NLRP3 inflammasome
Korean Red Ginseng extracts (RGE) have been suggested as effective immune modulators, and we reported that ginsenosides possess anti-inflammasome properties. However, the properties of non-saponin components of RGE have not been well studied.
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Evaluation of ginsenoside bioconversion of lactic acid bacteria isolated from kimchi
Panax ginseng is a physiologically active plant widely used in traditional medicine that is characterized by the presence of ginsenosides. Rb1, a major ginsenoside, is used as the starting material for producing ginsenoside derivatives with enhanced pharmaceutical potentials through chemical, enzymatic, or microbial transformation.
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Chronic saponin treatment attenuates damage to the pancreas in chronic alcohol-treated diabetic rats
Chronic heavy alcohol consumption may raise the risk of developing type 2 diabetes mellitus. Saponins inhibit apoptosis of pancreatic islet cells and reducing of lipid parameters. The present study was designed to investigate the effect of saponin on chronic ethanol-treated diabetic rats.
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Applications of molecular markers in the discrimination of species and Korean ginseng cultivars ()
The development of molecular markers is one of the most useful methods for molecular breeding and marker-based molecular associated selections. Even though less information of the reference genome, the molecular markers are indispensable tools for determination of genetic variation and identification of species with high levels of accuracy and reproducibility. The demand for molecular approaches for marker-based breeding and genetic discriminations in Panax species has greatly increased in recent times and has been successfully applied for various purposes.
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Korean Red Ginseng extract induces angiogenesis through activation of glucocorticoid receptor
Our previous studies have demonstrated that ginsenoside-Rg1 can promote angiogenesis in vitro and in vivo through activation of the glucocorticoid receptor (GR). Furthermore, microRNA (miRNA) expression profiling has shown that Rg1 can modulate the expression of a subset of miRNAs to induce angiogenesis. Moreover, Rb1 was shown to be anti-angiogenic through activation of a different pathway. These studies highlight the important functions of miRNAs on ginseng-regulated physiological processes. The aim of this study was to determine the angiogenic properties of Korean Red Ginseng extract (KGE).
