Pathogenesis-related (PR)-10 proteins are small, cytosolic proteins with a similar three-dimensional (3-D) structure. Crystal structures for several PR-10 homologs have similar overall folding patterns with an unusually large internal cavity that is a binding site for biologically important molecules. Although structural information on PR-10 proteins is substantial, understanding of their biological function remains limited. Here, we showed that one of the PgPR-10 homologs, PgPR-10.3, shares binding properties with flavonoids, kinetin, emodin, deoxycholic acid and ginsenoside Re (one of the steroid glycosides).

The present study aimed to compare the relative abundance of proteins and amino acid metabolites to explore the mechanisms underlying the difference between wild and cultivated ginseng (Panax ginseng Meyer) at the amino acid level.

Ginseng has been used as a tonic for invigoration of human body. In a previous report, we identified a novel candidate responsible for the tonic role of ginseng, designated gintonin. Gintonin induces [Ca2+]i transient in animal cells via lysophosphatidic acid (LPA) receptor activation. Gintonin-mediated [Ca2+]i transient is linked to anti-Alzheimer’s disease in transgenic Alzheimer’s disease animal model. The previous method for gintonin preparation included multiple steps. The aim of this study is to develop a simple method of gintonin fraction with a high yield.

Minor saponins or human intestinal bacterial metabolites such as ginsenoside Rg3, F2, Rh2, and compound K are more pharmacologically active than major saponins such as ginsenoside Rb1, Rb2, and Rc. In this study, enzymatic hydrolysis of ginsenoside Rb1 was studied using enzyme preparations from cultured mycelia of mushrooms.

Rhizobacteria play an important role in plant defense and could be promising sources of biocontrol agents. This study aimed to screen antagonistic bacteria and develop a biocontrol system for root rot complex of P. notoginseng.

Study on the phenolic compounds profiles and antioxidative activity in ginseng fruit, leaves, and roots depend on the cultivation years have been little reported so far. Hence, this study examined phenolic compounds profiles and 2, 2-diphenyl-1-picrylhydrazyl (DPPH) free-radical-scavenging activities in the fruit, leaves, and roots of Korean ginseng (Panax ginseng Meyer) as a function of cultivation years.

Red ginseng (RG) is processed from Panax ginseng via several methods including heat treatment, mild acid hydrolysis and microbial conversion to transform the major ginsenosides into minor ginsenosides, which have greater pharmaceutical activities. During the fermentation process using microbial strains in a machine for making red ginseng, a change of composition occurs after heating. Therefore, we confirmed that fermentation had occurred using only microbial strains and evaluated the changes in the ginsenosides and their chemical composition.

Binding of adhesive proteins (i.e. fibrinogen, fibronectin, vitronectin) to platelet integrin glycoprotein IIb/IIIa (αIIb/β3) by various agonists (thrombin, collagen, ADP) involve in strength of thrombus. This study was carried out to evaluate antiplatelet effect of total saponin from Korean red ginseng (KRG-TS) by investigating whether KRG-TS inhibits thrombin-induced binding of fibrinogen and fibronectin to αIIb/β3.

This study compared the contents of prosapogenin depending on the extracting conditions of Red ginseng to provide basic information for developing Red ginseng-based functional foods. The content of ginsenosides Rg3 reached their heights at 24 hrs of extraction, followed by 36 hrs and 72 hrs of extraction at 100°C.

The roots of Panax ginseng contain noble tetracyclic triterpenoid saponins derived from dammarenediol-II. Dammarene-type ginsenosides are classified into the protopanaxadiol (PPD) and protopanaxatriol (PPT) groups based on their triterpene aglycone structures. Two cytochrome P450 (CYP) genes (CYP716A47 and CYP716A53v2) are critical for the production of PPD and PPT aglycones, respectively. CYP716A53v2 is a protopanaxadiol 6-hydroxylase that catalyzes PPT production from PPD in P. ginseng.