A Brief Method for the Preparation of Gintonin-Enriched Fraction from Ginseng

Ginseng has been used as a tonic for invigoration of human body. In a previous report, we identified a novel candidate responsible for the tonic role of ginseng, designated gintonin. Gintonin induces [Ca2+]i transient in animal cells via lysophosphatidic acid (LPA) receptor activation. Gintonin-mediated [Ca2+]i transient is linked to anti-Alzheimer’s disease in transgenic Alzheimer’s disease animal model. The previous method for gintonin preparation included multiple steps. The aim of this study is to develop a simple method of gintonin fraction with a high yield.