Ginsenoside-Rg3, the pharmacologically active component of red ginseng, has been found to inhibit tumor growth, invasion, metastasis, and angiogenesis in various cancer models. Previously, we found that 20(R)-ginsenoside-Rg3 (Rg3) could inhibit angiogenesis. Since microRNAs (miRNAs) have been shown to affect many biological processes, they might play an important role in ginsenoside-mediated angiomodulation. In this study, we examined the underlying mechanisms of Rg3-induced angiosuppression through modulating miRNA expression.

Wild ginseng Panax ginseng Meyer is an endangered species of medicinal plants. In the present study, we analyzed variations within the rDNA cluster to gain insight into the genetic diversity of the oriental ginseng Panax ginseng at artificial plant cultivation.

Ginseng (Panax ginseng Meyer) is a well characterized medicinal herb listed in the classic oriental herbal dictionary as “Shin-nong-bon-cho-kyung”. Ginseng bears diverse pharmacologic and therapeutic properties. Black ginseng (BG, Ginseng Radix Nigra) is produced by repeatedly steaming fresh ginseng nine times. Studies of BG have shown that prolonged heat-treatment enhances the antioxidant activity with increased radical scavenging activity. Several recent studies have showed the effects of black ginseng on increased lipid profiles in mice.

Chemotherapy-induced alopecia (CIA) is one of the most distressing side effects for patients undergoing chemotherapy. This study evaluated the protective effect of Korean Red Ginseng (KRG) on CIA in a well-established in vitro human hair follicle organ culture model as it occurs in vivo.

Adipocyte-macrophage communication plays a critical role regulating white adipose tissue (WAT) inflammatory gene expression. Because WAT inflammation contributes to the development of metabolic diseases, there is significant interest to understand how exogenous compounds regulate adipocyte-macrophage crosstalk. Previous work showed that an aqueous extract of North American ginseng (Panax quinquefolius) had strong inflammo-regulatory properties in adipocytes. The present study examined if different ginseng extracts influence adipocyte-macrophage crosstalk, as well as WAT inflammatory gene expression.

Nephrotoxicity is a common side effect of medications. Panax ginseng is one of the best-known herbal medicines and its individual constituents enhance renal function. Identification of its efficacy and mechanisms of action against drug-induced nephrotoxicity as well as the specific constituents mediating this effect have recently emerged as an interesting research area focusing on the kidney-protective efficacy of P. ginseng.

The aim of this study was to evaluate the effects of Red Ginseng marc with alum as litter amendments on ammonia, soluble reactive phosphorus, and pathogen populations in poultry litters.