Panax ginseng is a physiologically active plant widely used in traditional medicine that is characterized by the presence of ginsenosides. Rb1, a major ginsenoside, is used as the starting material for producing ginsenoside derivatives with enhanced pharmaceutical potentials through chemical, enzymatic, or microbial transformation.
Tag Archives: ginseng
Chronic saponin treatment attenuates damage to the pancreas in chronic alcohol-treated diabetic rats
Chronic heavy alcohol consumption may raise the risk of developing type 2 diabetes mellitus. Saponins inhibit apoptosis of pancreatic islet cells and reducing of lipid parameters. The present study was designed to investigate the effect of saponin on chronic ethanol-treated diabetic rats.
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Applications of molecular markers in the discrimination of species and Korean ginseng cultivars ()
The development of molecular markers is one of the most useful methods for molecular breeding and marker-based molecular associated selections. Even though less information of the reference genome, the molecular markers are indispensable tools for determination of genetic variation and identification of species with high levels of accuracy and reproducibility. The demand for molecular approaches for marker-based breeding and genetic discriminations in Panax species has greatly increased in recent times and has been successfully applied for various purposes.
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Korean Red Ginseng extract induces angiogenesis through activation of glucocorticoid receptor
Our previous studies have demonstrated that ginsenoside-Rg1 can promote angiogenesis in vitro and in vivo through activation of the glucocorticoid receptor (GR). Furthermore, microRNA (miRNA) expression profiling has shown that Rg1 can modulate the expression of a subset of miRNAs to induce angiogenesis. Moreover, Rb1 was shown to be anti-angiogenic through activation of a different pathway. These studies highlight the important functions of miRNAs on ginseng-regulated physiological processes. The aim of this study was to determine the angiogenic properties of Korean Red Ginseng extract (KGE).
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Antiviral activity of 20()-ginsenoside Rh2 against murine gammaherpesvirus
Ginsenosides are the major components of Panax ginseng Meyer, an herbal medicine used for the treatment of various diseases. Different ginsenosides contribute to the biological properties of ginseng, such as antimicrobial, anticancer, and immunomodulatory properties. In this study, we investigated the antiviral effects of 15 ginsenosides and compound K on gammaherpesvirus.
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Chemical and bioactive comparison of flowers of Meyer, L. and Burk
Although flowers of Panax ginseng Meyer ( FPG ), Panax quinquefolius L.( FPQ ) and Panax notoginseng Burk. ( FPN ) have been historically used as both medicine and food, individual was differently used in practice.
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Chemical transformation and target preparation of saponins in stems and leaves of
Notoginsenoside Ft1 was a promising potential candidate for cardiovascular and cancer disease therapy owing to its positive pharmacological activities. However, the yield of Ft1 is ultra-low utilizing reported methods. Herein, an acid hydrolyzing strategy was implemented in the acquirement of rare notoginsenoside Ft1.
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and anti-inflammatory activities of Korean red ginseng-derived components
Although Korean red ginseng (KRG) has been traditionally used for a long time, its anti-inflammatory role and underlying molecular and cellular mechanisms have been poorly understood. In this study, the anti-inflammatory roles of KRG-derived components, namely water extract (KRG-WE), saponin fraction (KRG-SF), and non-saponin fraction (KRG-NSF), were investigated.
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Effects of Ginseng on Sex Steroid Hormone Estrogen and Androgen Receptors
Ginseng has been used in China for at least two millennia and is now popular in over 35 countries. It is one of the world’s popular herbs for complementary and alternative medicine and has been shown to have helpful effects on cognition and blood circulation, as well as anti-aging, anti-cancer, and anti-diabetic effects, among many others. The pharmacological activities of ginseng are dependent mainly on ginsenosides. Ginsenosides have a cholesterol-like four trans-ring steroid skeleton with a variety of sugar moieties.
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Enhanced antidiabetic efficacy and safety of the ginsenoside compound K in zebrafish by conjugation with β-cyclodextrin
20(S)-protopanaxadiol 20-O-D-glucopyranoside, or compound K (CK), exerts antidiabetic effects that are mediated by insulin secretion through KATP channels in pancreatic β-cells. However, the antidiabetic effects of CK may be limited due to its low bioavailability. Methods: In this study, we aimed to enhance the antidiabetic activity and lower the toxicity of CK by conjugation with β-cyclodextrin (CD) (CD-CK), and determined if the CD-CK compound enhanced pancreatic islet recovery compared with CK alone in an alloxan-induced zebrafish model.
