Ginsenoside Rd (GSRd), main components of the root of Panax ginseng, exhibit anti-inflammation functions and decrease infarct size in many injuries and ischemia diseases like focal cerebral ischemia. M1 Macrophages are regarded as one of the key inflammatory cells having functions for disease progression.
Tag Archives: ginseng
Development of a SNP Marker for Specific Authentication of Korean ginseng’s ( Meyer) New cultivar “G-1”
Korean ginseng (Panax ginseng) one of the well-known medicinal plant of Oriental medicine that is still in practice. A total of 11 Korean ginseng cultivars with unique features to Korean ginseng have been developed until now based on pure line selection method. Among them, a new cultivar namely G-1 with different agricultural traits related to yield and content of ginsenosides was developed in 2012.
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Microbial conversion of major ginsenosides in ginseng total saponins by endophytes
In this study, we screened and identified an endophyte JG09 having strong biocatalytic activity for ginsenosides from Platycodon grandiflorum (P. grandiflorum), converted ginseng total saponins and ginsenoside monomers, determined the source of minor ginsenosides and the transformation pathways, and calculated the maximum production of minor ginsenosides for the conversion of ginsenoside Rb1 to assess the transformation activity of endophyte JG09.
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Animal lectins: potential receptors for ginseng polysaccharides
Panax ginseng Meyer, belonging to the genus Panax of the family Araliaceae, is known for its human immune system-related effects such as immune-boosting effects. Ginseng polysaccharides (GPs) are the responsible ingredient of ginseng in immunomodulation, which are classified as acidic and neutral GPs. Although GPs participate in various immune reactions including the stimulation of immune cells and production of cytokines, the precise function of GPs together with its potential receptor(s) and their signal transduction pathways have remained largely unknown.
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Determination of ginsenosides in Asian and American Ginsengs by liquid chromatography-quadrupole/time of flight-mass spectrometry: assessing variations based on morphological characteristics
Asian ginseng and American ginseng are functional food that share a close genetic relationship and are well-known worldwide. This article aims to investigate the correlation between morphological characteristics and the inherent quality of Asian and American ginsengs.
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Discrimination of Korean ginseng ( Meyer) cultivar Chunpoong and American ginseng () using the gene
Korean ginseng (Panax ginseng) is one of the most important medicinal plants in the Orient. Among nine cultivars of P. ginseng, Chunpoong commands a much greater market value and has been planted widely in Korea. Chunpoong has superior quality “Chunsam (1st grade ginseng) when made into red ginseng.
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Ginsenoside Rg1 suppresses early stage of adipocyte development via activation of CHOP10 in 3T3-L1 and attenuates fat accumulation in high fat diet-induced obese zebrafish
Ginsenoside Rg1 is a class of steroid glycoside and triterpene saponin in Panax ginseng. Many studies suggest that Rg1 suppress adipocyte differentiation in 3T3-L1. However, the detail molecular mechanism of Rg1 on adipogenesis in 3T3-L1 has still not been fully understood yet.
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Effect of Red Ginseng on Cytochrome P450 and P-glycoprotein Activities in Healthy Volunteers
We evaluated the drug interaction profile of red ginseng (RG) with respect to the activities of major cytochrome P450 (CYP) enzymes and the drug transporter P-glycoprotein (P-gp) in healthy Korean volunteers.
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VASP-phosphorylation by ginsenoside Ro inhibits fibrinogen binding to αIIb/β in thrombin-induced human platelets
Glycoprotein IIb/IIIa (αIIb/β3) is involved in platelet adhesion, and triggers a series of intracellular signaling cascade, leading to platelet shape change, granule secretion and clot retraction. In this study, we evaluated the effect of ginsenoside Ro (G-Ro) on the binding of fibrinogen to αIIb/β3.
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Identification of mountain cultivated ginseng and cultivated ginseng using UPLC–oa-TOF MSE with a Multivariate Statistical Sample Profiling Strategy
The mountain cultivated ginseng (MCG) and cultivated ginseng (CG) both belong to the Panax ginseng, which have similar ingredients. However, their pharmacological activities are obviously different due to the significant differences in growth environment.
