GF1 suppresses dendrite formation of melanocytes, resulting in inhibition of melanosome transfer into keratinocytes in human cell co-cultures and 3D-human skin equivalent. Our results suggested that GF1 is a potent ginsenoside possessing potential as a depigmentary agent for pigmentary disorders and a cosmetic ingredient for lightening of skin color.

The lepidopteran Asiatic corn borer (ACB), Ostriniafurnacalis (Guenee), has caused huge economic losses throughout the Asian-Western Pacific region. Usually, chemical pesticides are used to control, but excessive use of pesticides has caused great harm. Therefore, the inartificial ecotypic pesticides to ACB are extremely essential. In our previous study, we found that panaxadiol saponins (PDS) can effectively reduce the harm of ACB by causing antifeedant activity. So, it is necessary to reveal the biological molecular changes in ACB and the functionary mechanism of PDS.

Ginsenosides are the main ingredients of Korean red ginseng (KRG). They have extensively been studied for their beneficial value in neurodegenerative diseases like Parkinson’s disease (PD). However, the multitarget effects of KRG extract (KRGE) with various components are unclear.

Common features of neurodegenerative diseases (NDDs) include progressive dysfunctions and neuronal injuries leading to deterioration in normal brain functions. At present, ginseng is one of the most frequently used natural products and its use has a long history as a cure for various diseases because its extracts and active compounds exhibit several pharmacological properties against several disorders. However, the pathophysiology of NDDs is not fully clear, but researchers have been found that various ion channels and specific signaling pathways might be contributed to the disease pathogenesis.

Longevity in medicine can be defined as a long life without mental or physical deficits. This can be prevented by Alzheimer’s disease (AD). Current conventional AD treatments only alleviate the symptoms without reversing AD progression. Recent studies demonstrated that Panax ginseng extract improves AD symptoms in AD patients and the two main components of ginseng might contribute to AD amelioration. Ginsenosides show various AD-related neuroprotective effects. Gintonin is a newly identified ginseng constituent that contains lysophosphatidic acids (LPAs), and attenuates AD-related brain neuropathies.

Ginsenosides, dammarane-type triterpene saponins obtained from Ginseng, have been used as a natural medicine for many years in the Orient due to their various pharmacological activities. However, the therapeutic potential of ginsenosides has been largely limited by the low bioavailability of the natural products caused mainly by low aqueous solubility, poor biomembrane permeability, instability in the gastrointestinal tract, and extensive metabolism in the body. To enhance the bioavailability of ginsenosides, diverse micro-/nano-sized delivery systems such as emulsions, polymeric particles, and vesicular systems have been investigated.

Korean red ginseng has been widely used in traditional oriental medicine for a prolonged period and its pharmacological effects have been extensively investigated. In addition, angelica gigas and deer antlers were also used as a tonic medicine with Korean red ginseng as the oriental herbal therapy.

Thromboxane A2 (TXA2) induces platelet aggregation and promotes thrombus formation. Although ginsenoside Ro (G-Ro) from Panax ginseng is known to exhibit a Ca2+-antagonistic antiplatelet effect, whether it inhibits Ca2+-dependent cytosolic phospholipase A2 (cPLA2α) activity to prevent the release of arachidonic acid (AA), a TXA2 precursor, is unknown. In this study, we attempted to identify the mechanism underlying G-Ro-mediated TXA2 inhibition.

Panax ginseng is regarded as one of the best compounds for promoting health, and it has been used traditionally as a medicinal herb. Recently, Korean red ginseng (RG) has been shown to protect skin from aging and wrinkling; it can also relieve atopic dermatitis and allergy symptoms. This study aimed to evaluate RG’s effects on the regeneration of the full-thickness skin wounds in rat.

Inflammation is widespread in the clinical pathology and closely associated to the progress of many diseases. Triterpenoid saponins as a key group of active ingredients in Panax notoginseng (Burk.) F.H. Chen were demonstrated to show anti-inflammatory effects. However, the chemical structures of saponins in the leaves and stems of Panax notoginseng (PNLS) are still not fully clear. Herein, the isolation, purification and further evaluation of the anti-inflammation activity of dammarane-type triterpenoid saponins from PNLS were conducted.