Ginseng (Panax ginseng Meyer) is a well characterized medicinal herb listed in the classic oriental herbal dictionary as “Shin-nong-bon-cho-kyung”. Ginseng bears diverse pharmacologic and therapeutic properties. Black ginseng (BG, Ginseng Radix Nigra) is produced by repeatedly steaming fresh ginseng nine times. Studies of BG have shown that prolonged heat-treatment enhances the antioxidant activity with increased radical scavenging activity. Several recent studies have showed the effects of black ginseng on increased lipid profiles in mice.

Chemotherapy-induced alopecia (CIA) is one of the most distressing side effects for patients undergoing chemotherapy. This study evaluated the protective effect of Korean Red Ginseng (KRG) on CIA in a well-established in vitro human hair follicle organ culture model as it occurs in vivo.

Adipocyte-macrophage communication plays a critical role regulating white adipose tissue (WAT) inflammatory gene expression. Because WAT inflammation contributes to the development of metabolic diseases, there is significant interest to understand how exogenous compounds regulate adipocyte-macrophage crosstalk. Previous work showed that an aqueous extract of North American ginseng (Panax quinquefolius) had strong inflammo-regulatory properties in adipocytes. The present study examined if different ginseng extracts influence adipocyte-macrophage crosstalk, as well as WAT inflammatory gene expression.

Nephrotoxicity is a common side effect of medications. Panax ginseng is one of the best-known herbal medicines and its individual constituents enhance renal function. Identification of its efficacy and mechanisms of action against drug-induced nephrotoxicity as well as the specific constituents mediating this effect have recently emerged as an interesting research area focusing on the kidney-protective efficacy of P. ginseng.

The aim of this study was to evaluate the effects of Red Ginseng marc with alum as litter amendments on ammonia, soluble reactive phosphorus, and pathogen populations in poultry litters.

The ginsenoside F1, a pharmaceutical component of ginseng, is known to have anti-aging, anti-oxidant, anti-cancer, and keratinocyte protective effects. However, the usage of ginsenoside F1 is restricted owing to the small amounts found in Korean ginseng.

Rhizospheric fungi play an essential role in plant-soil ecosystem, affect plant growth and health. In this study, we evaluated the fungal diversity in the rhizosphere of 2-year-old healthy Panax notoginseng cultivated in Wenshan, China.

Pathogenesis-related (PR)-10 proteins are small, cytosolic proteins with a similar three-dimensional (3-D) structure. Crystal structures for several PR-10 homologs have similar overall folding patterns with an unusually large internal cavity that is a binding site for biologically important molecules. Although structural information on PR-10 proteins is substantial, understanding of their biological function remains limited. Here, we showed that one of the PgPR-10 homologs, PgPR-10.3, shares binding properties with flavonoids, kinetin, emodin, deoxycholic acid and ginsenoside Re (one of the steroid glycosides).

The present study aimed to compare the relative abundance of proteins and amino acid metabolites to explore the mechanisms underlying the difference between wild and cultivated ginseng (Panax ginseng Meyer) at the amino acid level.

Ginseng has been used as a tonic for invigoration of human body. In a previous report, we identified a novel candidate responsible for the tonic role of ginseng, designated gintonin. Gintonin induces [Ca2+]i transient in animal cells via lysophosphatidic acid (LPA) receptor activation. Gintonin-mediated [Ca2+]i transient is linked to anti-Alzheimer’s disease in transgenic Alzheimer’s disease animal model. The previous method for gintonin preparation included multiple steps. The aim of this study is to develop a simple method of gintonin fraction with a high yield.