Ginsenoside Rb1 ameliorates liver fat accumulation by up-regulating perilipin expression in adipose tissue of db/db obese mice

Ginsenoside Rb1 (G-Rb1), the major active constituent of ginseng, improves insulin sensitivity and exerts anti-diabetic effects. We tested whether the insulin-sensitizing and anti-diabetic effects of G-Rb1 results from a reduction in ectopic fat accumulation, mediated by inhibition of lipolysis in adipocytes.